(Q37994048)

26 August 2017

Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity (English)

1 reference

26 August 2017

1 reference

Ruslan Novosyadlyy

1

1 reference

PubMed ID

22421704

26 August 2017

Derek Leroith

series ordinal

2

1 reference

PubMed ID

22421704

26 August 2017

language of work or name

English

0 references

publication date

15 March 2012

1 reference

The Journals of Gerontology

26 August 2017

1 reference

26 August 2017

67

1 reference

26 August 2017

6

1 reference

26 August 2017

640-651

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

26 August 2017

1 reference

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The endocrine regulation of aging by insulin-like signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-like growth factors and neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Diabetes mellitus and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Expression of insulin-like growth factor I in cultured rat hepatocytes: effects of insulin and growth hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Biological effects of growth hormone on carbohydrate and lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin suppresses growth hormone secretion by rat pituitary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Cellular actions of the insulin-like growth factor binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Molecular and cellular aspects of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Molecular bases of progeroid syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Is growth hormone resistance/IGF-1 reduction good for you?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Reduced growth of human sarcoma xenografts in hosts homozygous for the lit mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Genetic mouse models of extended lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Role of insulin-like growth factors in embryonic and postnatal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Normal growth and development in the absence of hepatic insulin-like growth factor I

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Augmented Wnt signaling in a mammalian model of accelerated aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Lifespan extension in genetically modified mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

c-myc-induced hepatocarcinogenesis in the absence of IGF-I receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Insulin-like signaling, nutrient homeostasis, and life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Extended longevity in mice lacking the insulin receptor in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Brain IRS2 signaling coordinates life span and nutrient homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

mTOR and cancer: insights into a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Stressing the role of FoxO proteins in lifespan and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Forkhead-box transcription factors and their role in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Ubiquitin ligases: cell-cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Motif module map reveals enforcement of aging by continual NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Rapamycin extends maximal lifespan in cancer-prone mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGERONA%2FGLS065

21 January 2018

Identifiers

DOI

10.1093/GERONA/GLS065

1 reference

26 August 2017

1 reference

PubMed ID

22421704