(Q37998087)

26 August 2017

Thermodynamic studies for drug design and screening (English)

1 reference

26 August 2017

0 references

Jonathan B Chaires

2

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author name string

Nichola C Garbett

series ordinal

1

1 reference

PMC publication ID

3496183

26 August 2017

language of work or name

English

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publication date

8 March 2012

1 reference

Expert Opinion on Drug Discovery

26 August 2017

1 reference

26 August 2017

7

1 reference

26 August 2017

4

1 reference

26 August 2017

299-314

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Thermodynamics of binding interactions in the rational drug design process

26 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

A Discovery Funnel for Nucleic Acid Binding Drug Candidates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Higher throughput calorimetry: opportunities, approaches and challenges

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Thermodynamics guided lead discovery and optimization.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Fluorescence-based thermal shift assays

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

A medicinal chemist's guide to molecular interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

A thermodynamic approach to the affinity optimization of drug candidates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Do enthalpy and entropy distinguish first in class from best in class?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Calorimetry and thermodynamics in drug design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Universal screening methods and applications of ThermoFluor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Energetic basis of molecular recognition in a DNA aptamer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Designing ligands to bind proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Measurements of binding thermodynamics in drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Differential scanning calorimetry in life science: thermodynamics, stability, molecular recognition and application in drug design

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

High-density miniaturized thermal shift assays as a general strategy for drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Entropy-enthalpy compensation: fact or artifact?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Energetics of DNA intercalation reactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Isothermal titration calorimetry of protein-protein interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Significant discrepancies between van't Hoff and calorimetric enthalpies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Study of strong to ultratight protein interactions using differential scanning calorimetry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Thermodynamics of ligand binding and efficiency

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperatively binding ligands

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Measurement of enzyme kinetics and inhibitor constants using enthalpy arrays.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Microplate differential calorimetric biosensor for ascorbic acid analysis in food and pharmaceuticals.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

An autosampling differential scanning calorimeter instrument for studying molecular interactions

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

Adding calorimetric data to decision making in lead discovery: a hot tip

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3496183

1 October 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.666235

Chip calorimetry and its use for biochemical and cell biological investigations

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1517%2F17460441.2012.666235

Possible origin of differences between van't Hoff and calorimetric enthalpy estimates

21 January 2018

1 reference

12 December 2020

Overcoming roadblocks in lead optimization: a thermodynamic perspective

1 reference

12 December 2020

Stabilization of Proteins by Ligand Binding: Application to Drug Screening and Determination of Unfolding Energetics

1 reference

12 December 2020

Enthalpic Efficiency of Ligand Binding

1 reference

12 December 2020

Heat does not come in different colours: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions

1 reference

12 December 2020

Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand: a thermodynamic study of ligand binding to protein tyrosine phosphatase 1B

1 reference

12 December 2020

Thermal denaturation as tool to study DNA-ligand interactions

1 reference

12 December 2020

10.1517/17460441.2012.666235

Identifiers

DOI

1 reference

26 August 2017

1 reference

PMC publication ID

3496183

26 August 2017

PubMed publication ID

22458502

1 reference

PMC publication ID

3496183