(Q38000919)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

0 references

0 references

chronic myeloid leukemia

0 references

leukemia

1 reference

chronic lymphocytic leukemia

inferred from title

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Michaela Fontenay

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Olivier Bernard

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

F Damm

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

publication date

9 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

2027-2031

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

Frequent pathway mutations of splicing machinery in myelodysplasia

28 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The spliceosome: design principles of a dynamic RNP machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Nuclear pore proteins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Nup214 is required for CRM1-dependent nuclear protein export in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Spliceosome Structure and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Splicing-dependent RNA polymerase pausing in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Pause locally, splice globally

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Regulation of alternative splicing by histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

CRM1-mediated nuclear export: to the pore and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Initial genome sequencing and analysis of multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Molecular dissection of the 5q deletion in myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Analysis of the coding genome of diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Cooperative epigenetic modulation by cancer amplicon genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Pathogenesis of human B cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

The role of NOTCH1 signaling in T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

NOTCH1 mutations in CLL associated with trisomy 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Oncogenically active MYD88 mutations in human lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

Malignant pirates of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

TET2 and DNMT3A mutations in human T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.86

7 January 2021

Identifiers

DOI

10.1038/LEU.2012.86

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 January 2020

1004044982

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22484420%20AND%20SRC:MED&resulttype=core&format=json