(Q38007176)

26 August 2017

title

Lactoferrin: an alternative view of its role in human biological fluids (English)

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26 August 2017

David B Alexander

1

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26 August 2017

Masaaki Iigo

2

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26 August 2017

Koji Yamauchi

3

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26 August 2017

Masumi Suzui

4

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26 August 2017

Hiroyuki Tsuda

5

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26 August 2017

publication date

3 May 2012

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Biochemistry and Cell Biology

26 August 2017

published in

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26 August 2017

volume

90

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26 August 2017

issue

3

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26 August 2017

page(s)

279-306

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Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

26 August 2017

cites work

1 reference

Toll-like receptors: a family of pattern-recognition receptors in mammals

21 January 2018

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A Bactericidal Effect for Human Lactoferrin

21 January 2018

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Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection

21 January 2018

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Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal

21 January 2018

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Multifunctional host defense peptides: antimicrobial peptides, the small yet big players in innate and adaptive immunity

21 January 2018

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Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

21 January 2018

1 reference

Lactoferrin and iron: structural and dynamic aspects of binding and release

21 January 2018

1 reference

Molecular structure, binding properties and dynamics of lactoferrin

21 January 2018

1 reference

The lactoferrin receptor complex in Gram negative bacteria

21 January 2018

1 reference

Identification of the bactericidal domain of lactoferrin

21 January 2018

1 reference

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes

21 January 2018

1 reference

Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton

21 January 2018

1 reference

Antibacterial peptides: basic facts and emerging concepts

21 January 2018

1 reference

Neutrophil granules: a library of innate immunity proteins

21 January 2018

1 reference

A re-evaluation of the role of host defence peptides in mammalian immunity.

21 January 2018

1 reference

Impact of LL-37 on anti-infective immunity.

21 January 2018

1 reference

Immunomodulatory properties of defensins and cathelicidins

21 January 2018

1 reference

Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin

21 January 2018

1 reference

The antibacterial properties of secreted phospholipases A(2).

21 January 2018

1 reference

Bacterial cell membrane hydrolysis by secreted phospholipases A(2): a major physiological role of human group IIa sPLA(2) involving both bacterial cell wall penetration and interfacial catalysis.

21 January 2018

1 reference

Anti-microbial peptides: from invertebrates to vertebrates.

21 January 2018

1 reference

Concentration and fate of histatins and acidic proline-rich proteins in the oral environment

21 January 2018

1 reference

Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia

21 January 2018

1 reference

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

21 January 2018

1 reference

Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye view

21 January 2018

1 reference

Cationic polypeptides are required for antibacterial activity of human airway fluid.

21 January 2018

1 reference

Iron homeostasis in the neonate

21 January 2018

1 reference

The lactoperoxidase system links anion transport to host defense in cystic fibrosis

21 January 2018

1 reference

The type III secretion injectisome

21 January 2018

1 reference

Lipid raft organization and function in brush borders of epithelial cells

21 January 2018

1 reference

Lipid raft organization and function in the small intestinal brush border

21 January 2018

1 reference

Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress

21 January 2018

1 reference

Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly

21 January 2018

1 reference

Antimicrobial peptides in defence of the oral and respiratory tracts

21 January 2018

1 reference

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

21 January 2018

1 reference

Host defense peptides in the oral cavity and the lung: similarities and differences

21 January 2018

1 reference

The roles of antimicrobial peptides in innate host defense

21 January 2018

1 reference

Mucus clearance and lung function in cystic fibrosis with hypertonic saline

21 January 2018

1 reference

The peptidoglycan recognition proteins (PGRPs).

21 January 2018

1 reference

Killing of gram-negative bacteria by lactoferrin and lysozyme

21 January 2018

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Lactoferrin and transferrin damage of the gram-negative outer membrane is modulated by Ca2+ and Mg2+.

21 January 2018

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Airway mucus function and dysfunction

21 January 2018

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Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection

21 January 2018

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Mechanisms and function of DUOX in epithelia of the lung

21 January 2018

1 reference

Role of lactoferrin in the tear film.

21 January 2018

1 reference

Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores

21 January 2018

1 reference

Cell-wall determinants of the bactericidal action of group IIA phospholipase A2 against Gram-positive bacteria.

21 January 2018

1 reference

Antimicrobial polypeptides in host defense of the respiratory tract

21 January 2018

1 reference

Antimicrobial polypeptides

21 January 2018

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Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan

21 January 2018

1 reference

The lactoperoxidase system functions in bacterial clearance of airways

21 January 2018

1 reference

Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties

21 January 2018

1 reference

Distribution of mucins at the ocular surface

21 January 2018

1 reference

The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture

21 January 2018

1 reference

Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon

21 January 2018

1 reference

Antimicrobial peptides and periodontal disease

21 January 2018

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Membrane-tethered mucins have multiple functions on the ocular surface.

21 January 2018

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The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells

21 January 2018

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Collectins and cationic antimicrobial peptides of the respiratory epithelia.

21 January 2018

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Impact of the glycostructure of amphiphilic membrane components on the function of the outer membrane of Gram-negative bacteria as a matrix for incorporated channels and a target for antimicrobial peptides or proteins.

21 January 2018

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Structure and biological roles of mucin-type O-glycans at the ocular surface

21 January 2018

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Oxygen toxicity, oxygen radicals, transition metals and disease

21 January 2018

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Breast milk and defence against infection in the newborn

21 January 2018

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Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods

21 January 2018

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Antimicrobial factors in the cervical mucus plug.

21 January 2018

1 reference

Amniotic-fluid Lactoferrin: A Marker for Subclinical Intraamniotic Infection Prior to 32 Weeks Gestation

21 January 2018

1 reference

Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites

21 January 2018

1 reference

Collectins and their role in lung immunity

21 January 2018

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Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis

21 January 2018

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Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent

21 January 2018

1 reference

Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin

21 January 2018

1 reference

Strategies for new antimicrobial proteins and peptides: lysozyme and aprotinin as model molecules

21 January 2018

1 reference

Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens.

21 January 2018

1 reference

Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition

21 January 2018

1 reference

Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance.

21 January 2018

1 reference

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

21 January 2018

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A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population.

21 January 2018

1 reference

The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

21 January 2018

1 reference

Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems

21 January 2018

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Lactoferrin levels in normal human tears

21 January 2018

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Intestinal goblet cells and mucins in health and disease: recent insights and progress

21 January 2018

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Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection

21 January 2018

1 reference

The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3.

21 January 2018

1 reference

Myeloperoxidase: friend and foe

21 January 2018

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Mucus clearance as a primary innate defense mechanism for mammalian airways

21 January 2018

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Role of host-defence peptides in eye diseases

21 January 2018

1 reference

Pulmonary collectins in innate immunity of the lung

21 January 2018

1 reference

Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis.

21 January 2018

1 reference

Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon

21 January 2018

1 reference

Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica.

21 January 2018

1 reference

Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection

21 January 2018

1 reference

Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes

21 January 2018

1 reference

Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli

21 January 2018

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Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.

21 January 2018

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21 January 2018

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Mucins in the mucosal barrier to infection.

21 January 2018

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Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency

21 January 2018

1 reference

Peptidoglycan recognition proteins are a new class of human bactericidal proteins

21 January 2018

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Lung infections associated with cystic fibrosis

21 January 2018

1 reference

The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoa

21 January 2018

1 reference

Functions of ocular surface mucins in health and disease

21 January 2018

1 reference

Mouse Lysozyme M Is Important in Pulmonary Host Defense againstKlebsiella pneumoniaeInfection

21 January 2018

1 reference

Distribution of transferrin, ferritin, and lactoferrin in human tissues

21 January 2018

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Immunohistochemical localization and bacteriostatic properties of an iron-binding protein from bronchial mucus

21 January 2018

1 reference

The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung

21 January 2018

1 reference

The in vitro activity of selected defensins against an isolate of Pseudomonas in the presence of human tears

21 January 2018

1 reference

Mucin dynamics and enteric pathogens.

21 January 2018

1 reference

Toll-like receptors and innate immunity

21 January 2018

1 reference

Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin

21 January 2018

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Secretory leukocyte protease inhibitor (SLPI) concentrations in cervical mucus of women with normal menstrual cycle

21 January 2018

1 reference

Characterization of the mouse beta defensin 1, Defb1, mutant mouse model.

21 January 2018

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beta-Defensin 1 contributes to pulmonary innate immunity in mice

21 January 2018

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Innate defenses of the intestinal epithelial barrier

21 January 2018

1 reference

Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model.

21 January 2018

1 reference

Secretory phospholipase A2.

21 January 2018

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Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand.

21 January 2018

1 reference

Lactoferrin--a novel bone growth factor

21 January 2018

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Protection of the neonate by the innate immune system of developing gut and of human milk

21 January 2018

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Innate host defense of the lung: effects of lung-lining fluid pH.

21 January 2018

1 reference

Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa

21 January 2018

1 reference

Molecular basis of bacterial outer membrane permeability

21 January 2018

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Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

21 January 2018

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Phagosome dynamics during phagocytosis by neutrophils

21 January 2018

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Lactoferrin disruption of bacterial type III secretion systems

21 January 2018

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Lactoferrin impairs type III secretory system function in enteropathogenic Escherichia coli

21 January 2018

1 reference

Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations

21 January 2018

1 reference

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine

21 January 2018

1 reference

Paneth cell α-defensins in enteric innate immunity

21 January 2018

1 reference

Paneth cell defensins and innate immunity of the small bowel

21 January 2018

1 reference

Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants

21 January 2018

1 reference

Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections

21 January 2018

1 reference

Bactericidal/permeability-increasing protein in lacrimal gland and in tears of healthy subjects

21 January 2018

1 reference

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.

21 January 2018

1 reference

Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae

21 January 2018

1 reference

CFTR function and prospects for therapy

21 January 2018

1 reference

Supplementation of an adapted formula with bovine lactoferrin: 1. Effect on the infant faecal flora

21 January 2018

1 reference

Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment

21 January 2018

1 reference

Ca2+ binding to bovine lactoferrin enhances protein stability and influences the release of bacterial lipopolysaccharide

21 January 2018

1 reference

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis

21 January 2018

1 reference

Host-defense mechanism of the ocular surfaces

21 January 2018

1 reference

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

21 January 2018

1 reference

Calcium ions induce collapse of charged O-side chains of lipopolysaccharides from Pseudomonas aeruginosa

21 January 2018

1 reference

Human antimicrobial proteins in ear wax.

21 January 2018

1 reference

How neutrophils kill microbes

21 January 2018

1 reference

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation.

21 January 2018

1 reference

Paneth cells and antibacterial host defense in neonatal small intestine

21 January 2018

1 reference

Human lactoferrin binds and removes the hemoglobin receptor protein of the periodontopathogen Porphyromonas gingivalis.

21 January 2018

1 reference

Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus

21 January 2018

1 reference

Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media

21 January 2018

1 reference

Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells

21 January 2018

1 reference

Iron sequestration by human lactoferrin stimulates P. aeruginosa surface motility and blocks biofilm formation

21 January 2018

1 reference

Production of beta-defensins by human airway epithelia

21 January 2018

1 reference

A component of innate immunity prevents bacterial biofilm development

21 January 2018

1 reference

Human beta-defensin-2: a natural antimicrobial peptide present in amniotic fluid participates in the host response to microbial invasion of the amniotic cavity.

21 January 2018

1 reference

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

21 January 2018

1 reference

Host defense peptides and their antimicrobial-immunomodulatory duality

21 January 2018

1 reference

Mammalian lactoferrin receptors: structure and function

21 January 2018

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Lactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors

21 January 2018

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Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts.

21 January 2018

1 reference

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase

21 January 2018

1 reference

Activity of abundant antimicrobials of the human airway

21 January 2018

1 reference

Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall

21 January 2018

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Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guérin by intelectin-1 deposited on cell surfaces

21 January 2018

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Antimicrobial components of vaginal fluid

21 January 2018

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Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis

21 January 2018

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Antiviral activities of lactoferrin

21 January 2018

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In vivo IgA coating of anaerobic bacteria in human faeces

21 January 2018

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IgA and the IgA Fc receptor.

21 January 2018

1 reference

One of Two Human Lactoferrin Variants Exhibits Increased Antibacterial and Transcriptional Activation Activities and Is Associated with Localized Juvenile Periodontitis

21 January 2018

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Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid

21 January 2018

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Modulation of in vitro fungicidal activity of human lactoferrin against Candida albicans by extracellular cation concentration and target cell metabolic activity

21 January 2018

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Interaction of lactoferrin with Escherichia coli cells and correlation with antibacterial activity.

21 January 2018

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Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor

21 January 2018

1 reference

Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia

21 January 2018

1 reference

Characterization of an eppin protein complex from human semen and spermatozoa

21 January 2018

1 reference

APD2: the updated antimicrobial peptide database and its application in peptide design

21 January 2018

1 reference

Lactoferrin: role in iron homeostasis and host defense against microbial infection

21 January 2018

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Iron status in mice carrying a targeted disruption of lactoferrin

21 January 2018

1 reference

Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice

21 January 2018

1 reference

Iron availability and infection

21 January 2018

1 reference

Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate

21 January 2018

1 reference

Antibody-enhanced pneumococcal adherence requires IgA1 protease.

21 January 2018

1 reference

Multiple components contribute to ability of saliva to inhibit influenza viruses

21 January 2018

1 reference

Antimicrobial peptides: the ancient arm of the human immune system

21 January 2018

1 reference

Lactoperoxidase and human airway host defense

21 January 2018

1 reference

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

21 January 2018

1 reference

Neutrophils: molecules, functions and pathophysiological aspects

21 January 2018

1 reference

Intelectin: a novel lipid raft-associated protein in the enterocyte brush border

21 January 2018

1 reference

Beta-defensin-2 promotes resistance against infection with P. aeruginosa

21 January 2018

1 reference

Association between lactoferrin gene polymorphisms and aggressive periodontitis among Taiwanese patients.

21 January 2018

1 reference

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.

21 January 2018

1 reference

Synergistic interactions between mammalian antimicrobial defense peptides

21 January 2018

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Mechanisms of antimicrobial peptide action and resistance

21 January 2018

1 reference

Antimicrobial peptides of multicellular organisms

21 January 2018

1 reference

Proteomic analysis of human tears: defensin expression after ocular surface surgery.

21 January 2018

1 reference

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

21 January 2018

1 reference

Glandular secretion of lactoferrin in a patient with neutrophil lactoferrin deficiency

21 January 2018

1 reference

Growth and adsorption of Streptococcus mutans 6715-13 to hydroxyapatite in the presence of lactoferrin

21 January 2018

1 reference

Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes

21 January 2018

1 reference

Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolyticaThis paper is one of a selection of papers published in this Special Issue, entitled 7th International Conference on Lactofer

21 January 2018

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Lactoferrin in intrauterine infection, human parturition, and rupture of fetal membranes

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/O2012-013

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26 August 2017

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