(Q38011247)

26 August 2017

title

Understanding efflux in Gram-negative bacteria: opportunities for drug discovery (English)

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26 August 2017

main subject

Gram-negative bacteria

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1 reference

Herbert P Schweizer

1

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26 August 2017

language of work or name

English

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publication date

19 May 2012

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Expert Opinion on Drug Discovery

26 August 2017

published in

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26 August 2017

volume

7

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26 August 2017

issue

7

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26 August 2017

page(s)

633-642

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Challenges of antibacterial discovery

26 August 2017

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21 January 2018

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Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

21 January 2018

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Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay

21 January 2018

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Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

21 January 2018

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Potent inhibitors of LpxC for the treatment of Gram-negative infections

21 January 2018

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Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa

21 January 2018

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Bacterial resistance to antibiotics: active efflux and reduced uptake

21 January 2018

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A coordinated network of transporters with overlapping specificities provides a robust survival strategy.

21 January 2018

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Nonenzymatic chloramphenicol resistance mediated by IncC plasmid R55 is encoded by a floR gene variant

21 January 2018

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Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance

21 January 2018

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New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors

21 January 2018

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Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria

21 January 2018

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Molecular basis of bacterial resistance to chloramphenicol and florfenicol

21 January 2018

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Efflux pumps and nosocomial antibiotic resistance: a primer for hospital epidemiologists

21 January 2018

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Detection of tetracyclines and efflux pump inhibitors

21 January 2018

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Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance

21 January 2018

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Efflux-mediated antimicrobial resistance

21 January 2018

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A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli

21 January 2018

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Inactivation of efflux pumps abolishes bacterial biofilm formation

21 January 2018

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Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa.

21 January 2018

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The TolC protein of Legionella pneumophila plays a major role in multi-drug resistance and the early steps of host invasion

21 January 2018

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The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis.

21 January 2018

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Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence

21 January 2018

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

21 January 2018

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Crystal structure of bacterial multidrug efflux transporter AcrB

21 January 2018

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

21 January 2018

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Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.

21 January 2018

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Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Bacterial efflux pump inhibitors from natural sources.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Bacterial efflux pump inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Inhibitors of multidrug resistant efflux systems in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Microbial efflux pump inhibition: tactics and strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat gram-negative resistant bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

A phenylalanine-arginine beta-naphthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Activity of the efflux pump inhibitor phenylalanine-arginine β-naphthylamide against the AdeFGH pump of Acinetobacter baumannii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Evaluation and target validation of indole derivatives as inhibitors of the AcrAB-TolC efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Gene-specific silencing induced by parallel complementary RNA in Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Restoration of antibiotic susceptibility in fluoroquinolone-resistant Escherichia coli by targeting acrB with antisense phosphorothioate oligonucleotide encapsulated in novel anion liposome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

Method for regulated expression of single-copy efflux pump genes in a surrogate Pseudomonas aeruginosa strain: identification of the BpeEF-OprC chloramphenicol and trimethoprim efflux pump of Burkholderia pseudomallei 1026b

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.688949

10.1517/17460441.2012.688949

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference