(Q38012259)

27 August 2017

Regulation of glucose transport by insulin: traffic control of GLUT4. (English)

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27 August 2017

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ChEBI release 2020-05-28

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2

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27 August 2017

Dara Leto

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27 August 2017

23 May 2012

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Nature Reviews Molecular Cell Biology

27 August 2017

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27 August 2017

13

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27 August 2017

383-396

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27 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrm3351

27 August 2017

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cites work

Regulated exocytosis: new organelles for non-secretory purposes

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Regulation of Weibel-Palade body exocytosis

31 March 2020

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The ins and outs of aquaporin-2 trafficking

31 March 2020

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Regulation of membrane expansion at the nerve growth cone.

31 March 2020

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Signaling pathways in insulin action: molecular targets of insulin resistance

31 March 2020

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Insulin signalling and the regulation of glucose and lipid metabolism

31 March 2020

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Glucose transporters in the 21st Century

31 March 2020

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Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

31 March 2020

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Biogenesis and regulation of insulin-responsive vesicles containing GLUT4.

31 March 2020

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Regulated transport of the glucose transporter GLUT4

31 March 2020

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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

31 March 2020

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

31 March 2020

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Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

31 March 2020

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

31 March 2020

1 reference

Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle

31 March 2020

1 reference

CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes

31 March 2020

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Insulin signal transduction and the IRS proteins

31 March 2020

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The insulin receptor: structure, function, and signaling

31 March 2020

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Role of Akt/protein kinase B in metabolism.

31 March 2020

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Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

31 March 2020

1 reference

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

31 March 2020

1 reference

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

31 March 2020

1 reference

Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

31 March 2020

1 reference

Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.

31 March 2020

1 reference

Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane

31 March 2020

1 reference

Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging.

31 March 2020

1 reference

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

31 March 2020

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Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

31 March 2020

1 reference

31 March 2020

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C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

31 March 2020

1 reference

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

31 March 2020

1 reference

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

31 March 2020

1 reference

A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes

31 March 2020

1 reference

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

31 March 2020

1 reference

The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

31 March 2020

1 reference

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

31 March 2020

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Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling

31 March 2020

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TC10alpha is required for insulin-stimulated glucose uptake in adipocytes

31 March 2020

1 reference

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

31 March 2020

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Promiscuous affairs of PKB/AKT isoforms in metabolism.

31 March 2020

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Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

31 March 2020

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Cloning and characterization of Cbl-associated protein splicing isoforms.

31 March 2020

1 reference

Insulin releases Glut4 from static storage compartments into cycling endosomes and increases the rate constant for Glut4 exocytosis

31 March 2020

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Lipid rafts are required for GLUT4 internalization in adipose cells

31 March 2020

1 reference

GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin

31 March 2020

1 reference

The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4.

31 March 2020

1 reference

Lipid rafts, caveolae, and their endocytosis

31 March 2020

1 reference

Adaptors for clathrin coats: structure and function.

31 March 2020

1 reference

Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4.

31 March 2020

1 reference

Dissecting dynamin's role in clathrin-mediated endocytosis.

31 March 2020

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Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling

31 March 2020

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Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes

31 March 2020

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Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein

31 March 2020

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Insulin accelerates inter-endosomal GLUT4 traffic via phosphatidylinositol 3-kinase and protein kinase B.

31 March 2020

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Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin

31 March 2020

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Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway

31 March 2020

1 reference

31 March 2020

1 reference

Compartment ablation analysis of the insulin-responsive glucose transporter (GLUT4) in 3T3-L1 adipocytes

31 March 2020

1 reference

The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells

31 March 2020

1 reference

Isolation and characterization of the two major intracellular Glut4 storage compartments

31 March 2020

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Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat

31 March 2020

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Sortilin is a major protein component of Glut4-containing vesicles

31 March 2020

1 reference

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling

31 March 2020

1 reference

Self-assembly of Glut4 storage vesicles during differentiation of 3T3-L1 adipocytes

31 March 2020

1 reference

Vesicle-associated membrane protein 2 plays a specific role in the insulin-dependent trafficking of the facilitative glucose transporter GLUT4 in 3T3-L1 adipocytes.

31 March 2020

1 reference

Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface

31 March 2020

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GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps

31 March 2020

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Dual-mode of insulin action controls GLUT4 vesicle exocytosis

31 March 2020

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GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif

31 March 2020

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GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes

31 March 2020

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AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

31 March 2020

1 reference

Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5

31 March 2020

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Rab proteins as membrane organizers

31 March 2020

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A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes

31 March 2020

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Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.

31 March 2020

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The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes

31 March 2020

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Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

31 March 2020

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Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane

31 March 2020

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Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

31 March 2020

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Rab10 in insulin-stimulated GLUT4 translocation.

31 March 2020

1 reference

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

31 March 2020

1 reference

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

1 reference

Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C

31 March 2020

1 reference

Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

31 March 2020

1 reference

A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes

31 March 2020

1 reference

The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles

31 March 2020

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An ACAP1-containing clathrin coat complex for endocytic recycling

31 March 2020

1 reference

Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.

31 March 2020

1 reference

Molecular mechanisms controlling GLUT4 intracellular retention

31 March 2020

1 reference

Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes

31 March 2020

1 reference

Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments

31 March 2020

1 reference

The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes

31 March 2020

1 reference

The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes

31 March 2020

1 reference

Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking

31 March 2020

1 reference

Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes

31 March 2020

1 reference

Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells.

31 March 2020

1 reference

Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c

31 March 2020

1 reference

The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

31 March 2020

1 reference

Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking

31 March 2020

1 reference

DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes

31 March 2020

1 reference

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

31 March 2020

1 reference

Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy

31 March 2020

1 reference

GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualized with green-fluorescent protein

31 March 2020

1 reference

Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules

31 March 2020

1 reference

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

31 March 2020

1 reference

GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay

31 March 2020

1 reference

Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes

31 March 2020

1 reference

Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway

31 March 2020

1 reference

Identification of a distal GLUT4 trafficking event controlled by actin polymerization

31 March 2020

1 reference

A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation

31 March 2020

1 reference

Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation

31 March 2020

1 reference

Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c

31 March 2020

1 reference

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion

31 March 2020

1 reference

A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division

31 March 2020

1 reference

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

31 March 2020

1 reference

Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling

31 March 2020

1 reference

Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering

31 March 2020

1 reference

The exocyst complex in polarized exocytosis

31 March 2020

1 reference

Exocyst function is regulated by effector phosphorylation.

31 March 2020

1 reference

Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane

31 March 2020

1 reference

Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells

31 March 2020

1 reference

Membrane association and functional regulation of Sec3 by phospholipids and Cdc42

31 March 2020

1 reference

PI(4,5)P(2) regulation of surface membrane traffic

31 March 2020

1 reference

The exocyst is a Ral effector complex

31 March 2020

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Ral GTPases regulate exocyst assembly through dual subunit interactions

31 March 2020

1 reference

The exocyst defrocked, a framework of rods revealed.

31 March 2020

1 reference

Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles

31 March 2020

1 reference

Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells

31 March 2020

1 reference

SNAREs--engines for membrane fusion

31 March 2020

1 reference

Functional studies in 3T3L1 cells support a role for SNARE proteins in insulin stimulation of GLUT4 translocation

31 March 2020

1 reference

Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins

31 March 2020

1 reference

Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport

31 March 2020

1 reference

SNARE proteins underpin insulin-regulated GLUT4 traffic.

31 March 2020

1 reference

At the junction of SNARE and SM protein function

31 March 2020

1 reference

Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes

31 March 2020

1 reference

Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells

31 March 2020

1 reference

Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes

31 March 2020

1 reference

Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle

31 March 2020

1 reference

Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization

31 March 2020

1 reference

Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles

31 March 2020

1 reference

Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance

31 March 2020

1 reference

Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking.

31 March 2020

1 reference

Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins

31 March 2020

1 reference

The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta

31 March 2020

1 reference

Membrane curvature in synaptic vesicle fusion and beyond.

31 March 2020

1 reference

Synip phosphorylation is required for insulin-stimulated Glut4 translocation

31 March 2020

1 reference

Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation

31 March 2020

1 reference

Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process

31 March 2020

1 reference

How synaptotagmin promotes membrane fusion.

31 March 2020

1 reference

Exocytosis: the many masters of the exocyst

31 March 2020

1 reference

Adipocytes as regulators of energy balance and glucose homeostasis

31 March 2020

1 reference

Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

31 March 2020

1 reference

Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes

31 March 2020

1 reference

12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

12 December 2020

Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake

1 reference

12 December 2020

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes

1 reference

12 December 2020

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action

1 reference

12 December 2020

Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization.

1 reference

12 December 2020

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1 reference

12 December 2020

Association of AP1 adaptor complexes with GLUT4 vesicles

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12 December 2020

Roles of the N- and C-termini of GLUT4 in endocytosis

1 reference

12 December 2020

Dose-response curves for in vivo insulin sensitivity in individual tissues in rats

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12 December 2020

Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling

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12 December 2020

Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes

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12 December 2020

Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

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12 December 2020

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells

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12 December 2020

Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells

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12 December 2020

The glucose transporter GLUT4 and the aminopeptidase vp165 colocalise in tubulo-vesicular elements in adipocytes and cardiomyocytes

1 reference

12 December 2020

Effects of insulin on intracellular GLUT4 vesicles in adipocytes: evidence for a secretory mode of regulation

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12 December 2020

Identifiers

DOI

10.1038/NRM3351

1 reference

PubMed ID

22617471

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22617471