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A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
scientific journal article
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scholarly article
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stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
title
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
(English)
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
main subject
V-ral simian leukemia viral oncogene A (ras related)
1 reference
stated in
GOA release 2020-03-11
Thymoma viral proto-oncogene 2
1 reference
stated in
GOA release 2020-03-11
Ral GTPase-activating protein subunit beta
1 reference
stated in
GOA release 2020-03-11
Exocyst complex component 4
1 reference
stated in
GOA release 2020-03-11
Exocyst complex component 7
1 reference
stated in
GOA release 2020-03-11
Ral GTPase activating protein, alpha subunit 2 (catalytic)
1 reference
stated in
GOA release 2020-03-11
preproinsulin
1 reference
based on heuristic
inferred from title
author
Alan Cheng
series ordinal
5
object named as
Alan Cheng
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PubMed
PubMed ID
21148297
retrieved
31 January 2017
Alan R. Saltiel
object named as
Alan R. Saltiel
series ordinal
7
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author name string
Xiao-Wei Chen
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
Dara Leto
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
Tingting Xiong
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
Genggeng Yu
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
Stuart Decker
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
publication date
1 January 2011
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stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
published in
Molecular Biology of the Cell
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
volume
22
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stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
page(s)
141–152
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stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
issue
1
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
cites work
Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
A complex interplay between Akt, TSC2 and the two mTOR complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
GEFs and GAPs: critical elements in the control of small G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Adipocytes contain a novel complex similar to the tuberous sclerosis complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Insulin signalling and the regulation of glucose and lipid metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Rho GTPases and the actin cytoskeleton
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
The GTPase superfamily: conserved structure and molecular mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
17 March 2017
Small GTP-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
7 April 2017
Rabs and their effectors: achieving specificity in membrane traffic
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
7 April 2017
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Small G proteins in insulin action: Rab and Rho families at the crossroads of signal transduction and GLUT4 vesicle traffic
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Rab10 in insulin-stimulated GLUT4 translocation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
The GLUT4 glucose transporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Regulation of small GTP-binding proteins by insulin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Bridging the GAP between insulin signaling and GLUT4 translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Changes in integrin expression during adipocyte differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
TSC2: filling the GAP in the mTOR signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Rheb fills a GAP between TSC and TOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Drosophila Rheb GTPase is required for cell cycle progression and cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Rheb promotes cell growth as a component of the insulin/TOR signalling network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Role of Akt/protein kinase B in metabolism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
The role of GTP-binding proteins in transport along the exocytic pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
29 September 2017
Complexity of the TOR signaling network.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
3 June 2018
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
3 June 2018
Signaling mechanistics: aluminum fluoride for molecule of the year
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
3 June 2018
Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
27 November 2018
23 genes, 23 years later
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
27 November 2018
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016972
retrieved
27 November 2018
Going for the GAP
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21148297
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ras family therapy: Rab, Rho and Ral talk to the exocyst
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21148297
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1091/MBC.E10-08-0665
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
PMCID
3016972
0 references
PubMed ID
21148297
1 reference
stated in
PubMed
PubMed ID
21148297
retrieved
31 January 2017
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