(Q38014575)

27 August 2017

title

Animal models for glioma drug discovery (English)

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27 August 2017

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Terreia S Jones

1

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27 August 2017

Eric C Holland

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

28 October 2011

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

6

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27 August 2017

issue

12

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27 August 2017

page(s)

1271-1283

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

27 August 2017

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Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma

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Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients

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A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

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A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma

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Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery

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Aggressive oligodendroglioma: a chemosensitive tumor

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Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults

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Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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21 January 2018

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Antiangiogenic therapies for high-grade glioma

21 January 2018

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Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience

21 January 2018

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FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme

21 January 2018

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Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme

21 January 2018

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The 2007 WHO classification of tumours of the central nervous system

21 January 2018

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'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

21 January 2018

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Molecular subclassification of diffuse gliomas: seeing order in the chaos

21 January 2018

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Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway

21 January 2018

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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

21 January 2018

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

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Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

21 January 2018

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

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21 January 2018

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Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo

21 January 2018

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PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

21 January 2018

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Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy

21 January 2018

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21 January 2018

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Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Human Brain Tumor Transplantation Into Nude Mice2

21 January 2018

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21 January 2018

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Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma

21 January 2018

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Development of a novel mouse glioma model using lentiviral vectors

21 January 2018

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Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

21 January 2018

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The multistep nature of cancer

21 January 2018

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Lessons from hereditary colorectal cancer

21 January 2018

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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

21 January 2018

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Cancer modeling in the modern era: progress and challenges

21 January 2018

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Inducible gene targeting in mice

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

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Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Modeling Adult Gliomas Using RCAS/t-va Technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

De novo induction of genetically engineered brain tumors in mice using plasmid DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632628

10.1517/17460441.2011.632628

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference