(Q38014898)

27 August 2017

title

5-azacytosine compounds in medicinal chemistry: current stage and future perspectives (English)

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27 August 2017

1

Marcela Krečmerová

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27 August 2017

Miroslav Otmar

2

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27 August 2017

publication date

1 May 2012

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Future Medicinal Chemistry

27 August 2017

published in

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27 August 2017

volume

4

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27 August 2017

issue

8

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27 August 2017

page(s)

991-1005

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Chemical decomposition of 5-aza-2'-deoxycytidine (Decitabine): kinetic analyses and identification of products by NMR, HPLC, and mass spectrometry.

27 August 2017

cites work

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The tumorigenicity of 5-azacytidine in the male Fischer rat.

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Carcinogenicity and haemoglobin synthesis induction by cytidine analogues

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Cellular differentiation, cytidine analogs and DNA methylation

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Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

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Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine

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DNA hypermethylation as a chemotherapy target

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Targeting DNA methylation for epigenetic therapy

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Epigenetic therapy of cancer: past, present and future

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A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

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Hypomethylating agents in the treatment of myelodysplastic syndromes and myeloid leukemia

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Pharmacokinetic evaluation of decitabine for the treatment of leukemia

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Adenosine A(2A) receptors measured with [C]TMSX PET in the striata of Parkinson's disease patients

21 January 2018

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Activity of azacitidine in chronic myelomonocytic leukemia.

21 January 2018

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Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer.

21 January 2018

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Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

21 January 2018

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Synthesis and antitumor activity of 5-azacytosine arabinoside

21 January 2018

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Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine

21 January 2018

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Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer and Leukemia Group B.

21 January 2018

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KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

21 January 2018

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Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases

21 January 2018

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Therapeutically targeting RNA viruses via lethal mutagenesis

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Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461

21 January 2018

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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

21 January 2018

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2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential

21 January 2018

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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

21 January 2018

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9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

21 January 2018

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New advances in anti-HSV chemotherapy.

21 January 2018

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Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture

21 January 2018

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Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents

21 January 2018

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Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds

21 January 2018

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Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase

21 January 2018

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Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum

21 January 2018

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Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity

21 January 2018

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Phosphonomethoxyalkyl Analogs of Nucleotides

21 January 2018

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Acyclic nucleoside phosphonates: a key class of antiviral drugs

21 January 2018

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The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond

21 January 2018

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Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base

21 January 2018

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Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections

21 January 2018

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Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position

21 January 2018

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Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy

21 January 2018

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Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

21 January 2018

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Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity

21 January 2018

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Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains

21 January 2018

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Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells.

21 January 2018

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In Vivo Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Cyclic Form

21 January 2018

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Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine

21 January 2018

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Design of Inhibitors of Orotidine Monophosphate Decarboxylase Using Bioisosteric Replacement and Determination of Inhibition Kinetics

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.12.36

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27 August 2017

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