(Q34464655)

2 August 2017

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title

Acyclic nucleoside phosphonates: a key class of antiviral drugs (English)

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2 August 2017

2

Antonín Holý

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2 August 2017

1

Erik De Clercq

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publication date

1 November 2005

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Nature Reviews Drug Discovery

2 August 2017

published in

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2 August 2017

volume

4

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2 August 2017

issue

11

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2 August 2017

page(s)

928-940

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https://scigraph.springernature.com/pub.10.1038/nrd1877

2 August 2017

exact match

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cites work

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Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

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Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata

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Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1.

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Ninety-six-week efficacy of combination therapy with lamivudine and tenofovir in patients coinfected with HIV-1 and wild-type hepatitis B virus

21 January 2018

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21 January 2018

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21 January 2018

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Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

21 January 2018

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Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

21 January 2018

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Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs

21 January 2018

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Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

21 January 2018

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Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

21 January 2018

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Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.

21 January 2018

1 reference

Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

21 January 2018

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Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir

21 January 2018

1 reference

Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge

21 January 2018

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The cotton rat model for adenovirus ocular infection: antiviral activity of cidofovir

21 January 2018

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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

21 January 2018

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Aryl ester prodrugs of cyclic HPMPC. I: Physicochemical characterization and in vitro biological stability

21 January 2018

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Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.

21 January 2018

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Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir

21 January 2018

1 reference

Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro

21 January 2018

1 reference

Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro

21 January 2018

1 reference

Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model

21 January 2018

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Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir

21 January 2018

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Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.

21 January 2018

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A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture

21 January 2018

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Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus

21 January 2018

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Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene

21 January 2018

1 reference

Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses

21 January 2018

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Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks

21 January 2018

1 reference

Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.

21 January 2018

1 reference

Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase

21 January 2018

1 reference

The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.

21 January 2018

1 reference

Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF.

21 January 2018

1 reference

Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.

21 January 2018

1 reference

Tenofovir resistance and resensitization

21 January 2018

1 reference

Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

21 January 2018

1 reference

Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients

21 January 2018

1 reference

Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases

21 January 2018

1 reference

21 January 2018

1 reference

Fanconi syndrome and acute renal failure in a patient treated with tenofovir: a call for caution

21 January 2018

1 reference

21 January 2018

1 reference

Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure

21 January 2018

1 reference

Renal safety of tenofovir in HIV treatment-experienced patients.

21 January 2018

1 reference

21 January 2018

1 reference

Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults

21 January 2018

1 reference

Pancreatitis in an HIV-infected person on a tenofovir, didanosine and stavudine containing highly active antiretroviral treatment

21 January 2018

1 reference

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

21 January 2018

1 reference

Unexpected drug interactions and adverse events with antiretroviral drugs

21 January 2018

1 reference

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue

21 January 2018

1 reference

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

21 January 2018

1 reference

Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates

21 January 2018

1 reference

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity

21 January 2018

1 reference

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity

21 January 2018

1 reference

Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

21 January 2018

1 reference

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

21 January 2018

1 reference

(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity

21 January 2018

1 reference

Synthesis of 5′-deoxyuridine 5′-phosphonic acid

31 March 2020

1 reference

Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells

31 March 2020

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Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation

31 March 2020

1 reference

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model

31 March 2020

1 reference

Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats

31 March 2020

1 reference

Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells.

31 March 2020

1 reference

Cidofovir for the treatment of Kaposi's sarcoma in an HIV-negative homosexual man

31 March 2020

1 reference

Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: report of a case

31 March 2020

1 reference

Tenofovir disoproxil fumarate

31 March 2020

1 reference

Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1877

1 reference

2 August 2017

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