(Q38016615)

27 August 2017

The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases (English)

1 reference

inflammatory bowel diseases

27 August 2017

0 references

author name string

Taeko Dohi

series ordinal

1

1 reference

PubMed ID

22672874

27 August 2017

Linda C Burkly

series ordinal

2

1 reference

27 August 2017

6 June 2012

1 reference

Journal of Leukocyte Biology

27 August 2017

1 reference

27 August 2017

92

1 reference

27 August 2017

2

1 reference

27 August 2017

265-279

1 reference

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

27 August 2017

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK, a multifunctional cytokine in kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK and the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Epithelium: the interplay between innate and Th2 immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Intestinal myofibroblasts: targets for stem cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK attenuates the transition from innate to adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Cytokine cooperation in renal tubular cell injury: the role of TWEAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The cytokine TWEAK modulates renal tubulointerstitial inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

NF-kappaB in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK is a positive regulator of cardiomyocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Development of an Fn14 agonistic antibody as an anti-tumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Multiple pathways of TWEAK-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

IL-17 enhances chemokine gene expression through mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Macrophages and tissue injury: agents of defense or destruction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Prevalence of ulcerative colitis and Crohn's disease in Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Gut, inflammation and osteoporosis: basic and clinical concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Regulation of homeostasis and inflammation in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Genetics and pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Oxidative stress in ulcerative colitis-associated carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Interactions between the host innate immune system and microbes in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Fecal HMGB1 Is a Novel Marker of Intestinal Mucosal Inflammation in Pediatric Inflammatory Bowel Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0112042

21 January 2018

Identifiers

DOI

10.1189/JLB.0112042

1 reference

27 August 2017

1 reference

PubMed ID

22672874