(Q38017216)

27 August 2017

title

Increasing the success rate of lantibiotic drug discovery by Synthetic Biology (English)

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27 August 2017

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Manuel Montalbán-López

1

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27 August 2017

Liang Zhou

2

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27 August 2017

Andrius Buivydas

3

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27 August 2017

Auke J van Heel

4

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27 August 2017

Oscar P Kuipers

5

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27 August 2017

language of work or name

English

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publication date

10 June 2012

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

7

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27 August 2017

issue

8

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27 August 2017

page(s)

695-709

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Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance

27 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Creeping baselines and adaptive resistance to antibiotics

21 January 2018

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Current concepts in antimicrobial therapy against select gram-positive organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci, and vancomycin-resistant enterococci

21 January 2018

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5 years of experience implementing a methicillin-resistant Staphylococcus aureus search and destroy policy at the largest university medical center in the Netherlands

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Methicillin resistant Staphylococcus aureus ST398 in veal calf farming: human MRSA carriage related with animal antimicrobial usage and farm hygiene

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Community-associated meticillin-resistant Staphylococcus aureus

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Role of antimicrobial selective pressure and secondary factors on antimicrobial resistance prevalence in Escherichia coli from food-producing animals in Japan

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Bacteriophage therapy: potential uses in the control of antibiotic-resistant pathogens

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Trends in antimicrobial drug development: implications for the future

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Lantibiotics: peptides of diverse structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Lantibiotics: mode of action, biosynthesis and bioengineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Protein engineering of lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Biosynthesis and mode of action of lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Genome mining for ribosomally synthesized natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Labyrinthopeptins: a new class of carbacyclic lantibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Production of dehydroamino acid-containing peptides by Lactococcus lactis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Multiple activities in lantibiotics--models for the design of novel antibiotics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Transcriptome analysis reveals mechanisms by which Lactococcus lactis acquires nisin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

MICs of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Are bacteriocins underexploited? Novel applications for old antimicrobials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Bovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Leader peptide-directed processing of labyrinthopeptin A2 precursor peptide by the modifying enzyme LabKC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Bacterial display and screening of posttranslationally thioether-stabilized peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Whole-cell matrix-assisted laser desorption/ionization mass spectrometry for rapid identification of bacteriocin/lantibiotic-producing bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Bacteriocin detection from whole bacteria by matrix-assisted laser desorption ionization-time of flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

A mass spectrometry-guided genome mining approach for natural product peptidogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

The generation of nisin variants with enhanced activity against specific gram-positive pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

BAGEL2: mining for bacteriocins in genomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

BAGEL: a web-based bacteriocin genome mining tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

BACTIBASE second release: a database and tool platform for bacteriocin characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Synthetic biology: integrated gene circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Heterologous expression, biosynthesis, and mutagenesis of type II lantibiotics from Bacillus licheniformis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Production of lantipeptides in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Lantibiotics: diverse activities and unique modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

On the regioselectivity of thioether formation by lacticin 481 synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

On the substrate specificity of dehydration by lacticin 481 synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Artificial lantipeptides from in vitro translations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Nine post-translational modifications during the biosynthesis of cinnamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.693476

10.1517/17460441.2012.693476

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

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