(Q38019416)

27 August 2017

title

Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more (English)

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27 August 2017

Xosé R Bustelo

1

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language of work or name

English

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publication date

18 June 2012

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27 August 2017

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27 August 2017

volume

34

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27 August 2017

issue

9

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27 August 2017

page(s)

748-759

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Tumor metastasis: molecular insights and evolving paradigms

27 August 2017

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Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

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ID genes mediate tumor reinitiation during breast cancer lung metastasis

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TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

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Endogenous human microRNAs that suppress breast cancer metastasis

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Genes that mediate breast cancer metastasis to the brain

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Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

21 January 2018

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Breast cancer methylomes establish an epigenomic foundation for metastasis

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

21 January 2018

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Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis

21 January 2018

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A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

21 January 2018

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Tumor self-seeding by circulating cancer cells

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Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

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The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

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Immunity, Inflammation, and Cancer

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Macrophage diversity enhances tumor progression and metastasis

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Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

21 January 2018

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Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

21 January 2018

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CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3

21 January 2018

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Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor

21 January 2018

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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

21 January 2018

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Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.

21 January 2018

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Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registry-based cohort study

21 January 2018

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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

21 January 2018

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Rho GTPases: biochemistry and biology

21 January 2018

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

21 January 2018

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Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

21 January 2018

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Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

21 January 2018

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Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

21 January 2018

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

21 January 2018

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Rac activation and inactivation control plasticity of tumor cell movement

21 January 2018

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RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation

21 January 2018

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DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells

21 January 2018

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Illuminating the metastatic process

21 January 2018

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200041

Real-time imaging reveals the single steps of brain metastasis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Degradation of RhoA by Smurf1 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

A MicroRNA targeting dicer for metastasis control

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

SUMOylation of the GTPase Rac1 is required for optimal cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Mutant p53 drives invasion by promoting integrin recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Rab GTPases implicated in inherited and acquired disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

IAP regulation of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

miR-200 enhances mouse breast cancer cell colonization to form distant metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Molecular definition of breast tumor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Chfr is linked to tumour metastasis through the downregulation of HDAC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial–mesenchymal transition of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Identification of an mRNP complex regulating tumorigenesis at the translational elongation step

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Activation of miR-31 function in already-established metastases elicits metastatic regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

A gene-expression signature as a predictor of survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

Converting a breast cancer microarray signature into a high-throughput diagnostic test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200041

21 January 2018

Identifiers

DOI

10.1002/BIES.201200041

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27 August 2017

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