(Q38019997)

27 August 2017

title

Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies (English)

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27 August 2017

main subject

arterial hypertension

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author

Augusto C Montezano

series ordinal

1

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27 August 2017

2

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27 August 2017

language of work or name

English

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publication date

1 June 2012

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27 August 2017

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27 August 2017

volume

44 Suppl 1

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27 August 2017

page(s)

S2-16

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Global noncommunicable diseases--where worlds meet

27 August 2017

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Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension

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Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.

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Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

21 January 2018

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gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension

21 January 2018

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Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats

21 January 2018

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Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension

21 January 2018

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Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

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Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

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The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans

21 January 2018

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Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients

21 January 2018

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Plasma vitamin C modifies the association between hypertension and risk of stroke

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Reactive oxygen species and vascular biology: implications in human hypertension

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Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

21 January 2018

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Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes

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Antioxidants in hypertension and cardiovascular disease

21 January 2018

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Superoxide anion radical (O2-.), superoxide dismutases, and related matters

21 January 2018

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Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers.

21 January 2018

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Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

21 January 2018

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Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators

21 January 2018

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NOX enzymes and the biology of reactive oxygen

21 January 2018

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NADPH oxidases: new kids on the block

21 January 2018

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NOX isoforms and reactive oxygen species in vascular health

21 January 2018

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Regulation of the phagocyte NADPH oxidase by Rac GTPase

21 January 2018

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Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease

21 January 2018

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Receptor activation of NADPH oxidases

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Vascular NAD(P)H oxidases: specific features, expression, and regulation

21 January 2018

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Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Activation of NADPH oxidase 1 in tumour colon epithelial cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: effects of nitrosothiol exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries

21 January 2018

1 reference

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Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Identification of renox, an NAD(P)H oxidase in kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox4 acts as a switch between differentiation and proliferation in preadipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox5 and the regulation of cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Cross-talk between mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction on angiotensin II-mediated increase in Nox isoform expression and activity in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NADPH oxidase 4 is an oncoprotein localized to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Role of extracellular superoxide dismutase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

The redox state of glutathione regulates the hypoxic induction of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Crosstalk signaling between mitochondrial Ca2+ and ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Role of reactive oxygen species in brainstem in neural mechanisms of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Impact of elevated dietary sodium intake on NAD(P)H oxidase and SOD in the cortex and medulla of the rat kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Oxidative stress and antioxidant treatment in hypertension and the associated renal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Tempol attenuates the development of hypertensive renal injury in Dahl salt-sensitive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Does superoxide underlie the pathogenesis of hypertension?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Decreased blood pressure in NOX1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Vascular structure and oxidative stress in salt-loaded spontaneously hypertensive rats: effects of losartan and atenolol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Superoxide mediates the actions of angiotensin II in the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Angiotensin II, oxidant signaling, and hypertension: down to a T?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Plasma hydrogen peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Racial differences in oxidative stress and inflammation: in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Vitamins C and E to prevent complications of pregnancy-associated hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

Hypotensive effect of atorvastatin is not related to changes in inflammation and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

NADPH oxidase inhibitors: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2011.653393

10.3109/07853890.2011.653393

21 January 2018

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DOI

1 reference

27 August 2017

1 reference