(Q38021701)

27 August 2017

Colorectal cancer and RASSF family--a special emphasis on RASSF1A. (English)

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27 August 2017

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27 August 2017

4

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27 August 2017

Fátima Carneiro

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author name string

Maria Sofia Fernandes

series ordinal

1

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PubMed ID

22733432

27 August 2017

language of work or name

English

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publication date

14 July 2012

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International Journal of Cancer

27 August 2017

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27 August 2017

132

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27 August 2017

2

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27 August 2017

251-258

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27 August 2017

Global cancer statistics

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Molecular origins of cancer: Molecular basis of colorectal cancer

21 January 2018

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KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

21 January 2018

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BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?

21 January 2018

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The prevalence of PIK3CA mutations in gastric and colon cancer.

21 January 2018

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Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

21 January 2018

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The dark side of Ras: regulation of apoptosis

21 January 2018

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RAS oncogenes: weaving a tumorigenic web

21 January 2018

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Death pathways triggered by activated Ras in cancer cells

21 January 2018

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Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer

21 January 2018

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21 January 2018

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Introduction to molecular and clinical genetics of colorectal cancer syndromes.

21 January 2018

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KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers

21 January 2018

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Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation

21 January 2018

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BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.

21 January 2018

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Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

21 January 2018

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GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

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Targeting the mitogen-activated protein kinase cascade to treat cancer

21 January 2018

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Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

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Identification of Nore1 as a potential Ras effector

21 January 2018

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

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RASSF1A: Not a prototypical Ras effector.

21 January 2018

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The RASSF1A tumor suppressor

21 January 2018

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Role of the Ras-association domain family 1 tumor suppressor gene in human cancers

21 January 2018

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Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.

21 January 2018

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Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

21 January 2018

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The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

21 January 2018

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Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas

21 January 2018

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Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.

21 January 2018

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Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer

21 January 2018

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Hypermethylation of RARβ2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma

21 January 2018

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Epigenetic alterations in RASSF1A in human aberrant crypt foci

21 January 2018

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RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A

21 January 2018

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Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.

21 January 2018

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Progressive methylation during the serrated neoplasia pathway of the colorectum.

21 January 2018

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Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features

21 January 2018

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Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients

21 January 2018

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Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.

21 January 2018

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RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

21 January 2018

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Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors

21 January 2018

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The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

21 January 2018

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CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.

21 January 2018

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Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers

21 January 2018

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Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.

21 January 2018

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Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer.

21 January 2018

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RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

21 January 2018

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Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

21 January 2018

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Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis

21 January 2018

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RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

21 January 2018

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The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

21 January 2018

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The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis

21 January 2018

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Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

21 January 2018

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Identification of a novel Ras-regulated proapoptotic pathway

21 January 2018

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Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

21 January 2018

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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

21 January 2018

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RASSF2 associates with and stabilizes the proapoptotic kinase MST2

21 January 2018

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The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

21 January 2018

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The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

21 January 2018

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The RASSF1A tumor suppressor activates Bax via MOAP-1.

21 January 2018

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Dynamics of RASSF1A/MOAP-1 association with death receptors.

21 January 2018

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The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation

21 January 2018

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RASSF1A suppresses the c-Jun-NH2-kinase pathway and inhibits cell cycle progression

21 January 2018

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Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene

21 January 2018

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Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest

21 January 2018

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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

21 January 2018

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The Ras effector RASSF2 controls the PAR-4 tumor suppressor

21 January 2018

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The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung

21 January 2018

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NORE1A tumor suppressor candidate modulates p21CIP1 via p53.

21 January 2018

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The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway

21 January 2018

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Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways

21 January 2018

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RASSF6 is a novel member of the RASSF family of tumor suppressors

21 January 2018

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Identification of RASSF8 as a candidate lung tumor suppressor gene

21 January 2018

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Control of microtubule stability by the RASSF1A tumor suppressor

21 January 2018

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RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

21 January 2018

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A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability

21 January 2018

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RAF/RAS oncogenes and mismatch-repair status

21 January 2018

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Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer

21 January 2018

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KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27696

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27 August 2017

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PubMed ID

22733432