(Q38021894)

27 August 2017

Prion propagation, toxicity and degradation (English)

1 reference

27 August 2017

0 references

1

1 reference

27 August 2017

Jeppe Falsig

2

1 reference

PubMed ID

22735515

27 August 2017

language of work or name

English

0 references

publication date

26 June 2012

1 reference

27 August 2017

1 reference

27 August 2017

15

1 reference

27 August 2017

7

1 reference

27 August 2017

936-939

1 reference

https://scigraph.springernature.com/pub.10.1038/nn.3120

27 August 2017

0 references

cites work

Mice devoid of PrP are resistant to scrapie

1 reference

Novel proteinaceous infectious particles cause scrapie

21 January 2018

1 reference

An analytical solution to the kinetics of breakable filament assembly

21 January 2018

1 reference

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

21 January 2018

1 reference

In vitro generation of infectious scrapie prions.

21 January 2018

1 reference

Formation of native prions from minimal components in vitro

21 January 2018

1 reference

Generating a prion with bacterially expressed recombinant prion protein

21 January 2018

1 reference

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

1 reference

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

21 January 2018

1 reference

Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

21 January 2018

1 reference

Prion protein and Abeta-related synaptic toxicity impairment

21 January 2018

1 reference

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

21 January 2018

1 reference

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

21 January 2018

1 reference

Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

21 January 2018

1 reference

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

21 January 2018

1 reference

Normal host prion protein necessary for scrapie-induced neurotoxicity.

21 January 2018

1 reference

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

21 January 2018

1 reference

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

21 January 2018

1 reference

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

21 January 2018

1 reference

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

21 January 2018

1 reference

Spontaneous generation of anchorless prions in transgenic mice

21 January 2018

1 reference

Prions: protein aggregation and infectious diseases

21 January 2018

1 reference

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

21 January 2018

1 reference

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

21 January 2018

1 reference

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

21 January 2018

1 reference

A transmembrane form of the prion protein in neurodegenerative disease

21 January 2018

1 reference

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration

21 January 2018

1 reference

Prion Topology and Toxicity

21 January 2018

1 reference

Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

21 January 2018

1 reference

Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells

21 January 2018

1 reference

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity

21 January 2018

1 reference

Ion channels induced by the prion protein: mediators of neurotoxicity.

21 January 2018

1 reference

Survival of scrapie virus after 3 years' interment

21 January 2018

1 reference

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

1 reference

Prion clearance in bigenic mice

21 January 2018

1 reference

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

21 January 2018

1 reference

Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells

21 January 2018

1 reference

A versatile prion replication assay in organotypic brain slices

21 January 2018

1 reference

Scrapie pathogenesis: the role of complement C1q in scrapie agent uptake by conventional dendritic cells.

21 January 2018

1 reference

Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles

21 January 2018

1 reference

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner

21 January 2018

1 reference

Cell division modulates prion accumulation in cultured cells

21 January 2018

1 reference

Prion strain discrimination in cell culture: the cell panel assay

21 January 2018

1 reference

Purified scrapie prions resist inactivation by UV irradiation

21 January 2018

1 reference

12 December 2020

Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

1 reference

12 December 2020

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

1 reference

12 December 2020

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.3120

1 reference

27 August 2017

1 reference

PubMed ID

22735515