(Q38025742)

27 August 2017

title

Update on carbonic anhydrase inhibitors: a patent review (2008 - 2011). (English)

1 reference

27 August 2017

Mayank Aggarwal

1

1 reference

27 August 2017

Robert McKenna

series ordinal

2

1 reference

27 August 2017

language of work or name

English

0 references

publication date

13 July 2012

1 reference

Expert Opinion on Therapeutic Patents

27 August 2017

published in

1 reference

27 August 2017

volume

22

1 reference

27 August 2017

issue

8

1 reference

27 August 2017

page(s)

903-915

1 reference

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrases: current state of the art, therapeutic applications and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structure and mechanism of carbonic anhydrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Identification of proton-transfer pathways in human carbonic anhydrase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Oxygen, a source of life and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: proposal of a unified hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Regulation of tumor pH and the role of carbonic anhydrase 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in nasopharyngeal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structural and Kinetic Study of the Extended Active Site for Proton Transfer in Human Carbonic Anhydrase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

VISCANA: visualized cluster analysis of protein-ligand interaction based on the ab initio fragment molecular orbital method for virtual ligand screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Application of the three-dimensional structures of protein target molecules in structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Is there a difference between leads and drugs? A historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

An Investigation Into the Prognostic Significance of Necrosis and Hypoxia in High Grade and Invasive Bladder Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors and activators and their use in therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors — Part 29 1: Interaction of isozymes I, II and IV with benzolamide-like derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors: X-ray and Molecular Modeling Study for the Interaction of a Fluorescent Antitumor Sulfonamide with Isozyme II and IX

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors: Synthesis of Water-Soluble, Aminoacyl/Dipeptidyl Sulfonamides Possessing Long-Lasting Intraocular Pressure-Lowering Properties via the Topical Route1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

Carbonic Anhydrase Inhibitors: Perfluoroalkyl/Aryl-Substituted Derivatives of Aromatic/Heterocyclic Sulfonamides as Topical Intraocular Pressure-Lowering Agents with Prolonged Duration of Action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.707646

10.1517/13543776.2012.707646

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference