(Q38027919)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

main subject

osteoarthritis

0 references

regenerative medicine

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Richard Oreffo

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Emma L Williams

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Christopher J Edwards

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

1 reference

1 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

published in

Regenerative Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

551-570

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

Biomaterials and mesenchymal stem cells for regenerative medicine.

8 February 2020

cites work

1 reference

Skeletal stem cells and bone regeneration: translational strategies from bench to clinic.

21 January 2018

1 reference

Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering.

21 January 2018

1 reference

The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair

21 January 2018

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Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study.

21 January 2018

1 reference

Instrumented fusion of thoracolumbar fracture with type I mineralized collagen matrix combined with autogenous bone marrow as a bone graft substitute: a four-case report

21 January 2018

1 reference

Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report.

21 January 2018

1 reference

Two techniques for the preparation of cell-scaffold constructs suitable for sinus augmentation: steps into clinical application.

21 January 2018

1 reference

Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalcium phosphate/hydroxyapatite scaffold.

21 January 2018

1 reference

Tissue-engineered bone for maxillary sinus augmentation.

21 January 2018

1 reference

Clinical transplantation of a tissue-engineered airway.

21 January 2018

1 reference

Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the various zones of articular cartilage

21 January 2018

1 reference

Differential effects of cyclic and static pressure on biochemical and morphological properties of chondrocytes from articular cartilage.

21 January 2018

1 reference

Bilayered scaffolds for osteochondral tissue engineering

21 January 2018

1 reference

Taking tissue-engineering principles into theater: augmentation of impacted allograft with human bone marrow stromal cells.

21 January 2018

1 reference

Bone morphogenetic proteins in clinical applications

21 January 2018

1 reference

Gene therapy in musculoskeletal repair.

21 January 2018

1 reference

Stem cells find their niche

21 January 2018

1 reference

Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp.

21 January 2018

1 reference

Skeletal stem cells: phenotype, biology and environmental niches informing tissue regeneration.

21 January 2018

1 reference

Obesity punches above its weight in osteoarthritis

21 January 2018

1 reference

Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

21 January 2018

1 reference

Inflammation in osteoarthritis

21 January 2018

1 reference

The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models

21 January 2018

1 reference

Are cytokines involved in osteoarthritic pathophysiology?

21 January 2018

1 reference

Cytokines and their role in the pathophysiology of osteoarthritis

21 January 2018

1 reference

Osteoarthritis and cartilage: the role of cytokines

21 January 2018

1 reference

Anticytokine therapy for osteoarthritis: evidence to date

21 January 2018

1 reference

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

21 January 2018

1 reference

A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis

21 January 2018

1 reference

Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology.

21 January 2018

1 reference

Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells.

21 January 2018

1 reference

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

21 January 2018

1 reference

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

21 January 2018

1 reference

Novel strategies for the treatment of osteoarthritis

21 January 2018

1 reference

Genetics and epigenetics of osteoarthritis.

21 January 2018

1 reference

Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions.

21 January 2018

1 reference

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage.

21 January 2018

1 reference

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes

21 January 2018

1 reference

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

21 January 2018

1 reference

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis

21 January 2018

1 reference

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

21 January 2018

1 reference

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

21 January 2018

1 reference

Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes

21 January 2018

1 reference

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes

21 January 2018

1 reference

Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes

21 January 2018

1 reference

Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis

21 January 2018

1 reference

MicroRNA in osteoarthritis

21 January 2018

1 reference

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.

21 January 2018

1 reference

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13.

21 January 2018

1 reference

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.

21 January 2018

1 reference

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

21 January 2018

1 reference

Expression of MicroRNA-146a in osteoarthritis cartilage

21 January 2018

1 reference

Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro.

21 January 2018

1 reference

IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes

21 January 2018

1 reference

Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci

21 January 2018

1 reference

Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes.

21 January 2018

1 reference

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.

21 January 2018

1 reference

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

21 January 2018

1 reference

Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

21 January 2018

1 reference

Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts

21 January 2018

1 reference

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study

21 January 2018

1 reference

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors

21 January 2018

1 reference

Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation

21 January 2018

1 reference

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

21 January 2018

1 reference

Vascular pathology and osteoarthritis

21 January 2018

1 reference

Is progressive osteoarthritis an atheromatous vascular disease?

21 January 2018

1 reference

Discoidin domain receptor 2 mediates the collagen II-dependent release of interleukin-6 in primary human chondrocytes.

21 January 2018

1 reference

Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone.

21 January 2018

1 reference

Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M.

21 January 2018

1 reference

Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis

21 January 2018

1 reference

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

21 January 2018

1 reference

Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts

21 January 2018

1 reference

Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?

21 January 2018

1 reference

Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism

21 January 2018

1 reference

Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

21 January 2018

1 reference

Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis.

21 January 2018

1 reference

Common endocrine control of body weight, reproduction, and bone mass

21 January 2018

1 reference

Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.

21 January 2018

1 reference

Osteoarthritis and obesity: experimental models.

21 January 2018

1 reference

Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model

21 January 2018

1 reference

Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies

21 January 2018

1 reference

Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.

21 January 2018

1 reference

21 January 2018

1 reference

Leukemia inhibitory factor: part of a large ingathering family

21 January 2018

1 reference

Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts

21 January 2018

1 reference

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro

21 January 2018

1 reference

Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells

21 January 2018

1 reference

Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts

21 January 2018

1 reference

Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts

21 January 2018

1 reference

Interleukin-17A induces cathepsin K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin E2 in osteoblasts

21 January 2018

1 reference

The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies

21 January 2018

1 reference

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

21 January 2018

1 reference

IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis

21 January 2018

1 reference

Pathophysiological roles for IL-18 in inflammatory arthritis

21 January 2018

1 reference

Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal

21 January 2018

1 reference

Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation

21 January 2018

1 reference

The roles of interleukin-18 in collagen-induced arthritis in the BB rat.

21 January 2018

1 reference

In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

21 January 2018

1 reference

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

21 January 2018

1 reference

Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience

21 January 2018

1 reference

Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model

21 January 2018

1 reference

Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

21 January 2018

1 reference

Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study

21 January 2018

1 reference

Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial

21 January 2018

1 reference

Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10.

21 January 2018

1 reference

Treatment of knee osteoarthritis with Orthokine-derived autologous conditioned serum

21 January 2018

1 reference

Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

21 January 2018

1 reference

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

21 January 2018

1 reference

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

21 January 2018

1 reference

rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions

21 January 2018

1 reference

Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically.

21 January 2018

1 reference

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

21 January 2018

1 reference

Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation

21 January 2018

1 reference

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

21 January 2018

1 reference

Cytokine targeting in osteoarthritis

21 January 2018

1 reference

Effects of strontium ranelate on spinal osteoarthritis progression.

21 January 2018

1 reference

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

21 January 2018

1 reference

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

21 January 2018

1 reference

Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis

21 January 2018

1 reference

Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes

21 January 2018

1 reference

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

21 January 2018

1 reference

Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13

21 January 2018

1 reference

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

21 January 2018

1 reference

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

21 January 2018

1 reference

Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.

21 January 2018

1 reference

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

21 January 2018

1 reference

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

1 reference

NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes

21 January 2018

1 reference

Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18

21 January 2018

1 reference

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

21 January 2018

1 reference

Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/RME.12.34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817628%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference