(Q38029115)

27 August 2017

title

Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs (English)

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27 August 2017

Frederick Monsma

2

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Rumin Zhang

object named as

Rumin Zhang

series ordinal

1

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language of work or name

English

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publication date

16 September 2010

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

5

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27 August 2017

issue

11

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27 August 2017

page(s)

1023-1029

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Drug-target residence time and its implications for lead optimization

27 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F17460441.2010.520700

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Biochemical mechanisms of drug action: what does it take for success?

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

21 January 2018

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Functional selectivity through protean and biased agonism: who steers the ship?

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Beyond thermodynamics: drug binding kinetics could influence epidermal growth factor signaling

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21 January 2018

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In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics

21 January 2018

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21 January 2018

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21 January 2018

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Cellular assays as portals to seven-transmembrane receptor-based drug discovery

21 January 2018

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Ligand detection in the allosteric world

21 January 2018

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Mechanism-based inhibition of cytochrome P450 enzymes: an evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods

21 January 2018

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Prediction of drug-drug interactions based on time-dependent inhibition from high throughput screening of cytochrome P450 3A4 inhibition

21 January 2018

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Impact of plasma-protein binding on receptor occupancy: an analytical description.

21 January 2018

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The importance of plasma protein binding in drug discovery

21 January 2018

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Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

21 January 2018

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Target site occupancy: emerging generalizations from clinical and preclinical studies

21 January 2018

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Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety

21 January 2018

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Adding calorimetric data to decision making in lead discovery: a hot tip

21 January 2018

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Computational modeling of biochemical networks using COPASI

21 January 2018

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COPASI--a COmplex PAthway SImulator

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10.1517/17460441.2010.520700

21 January 2018

Identifiers

DOI

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27 August 2017

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