(Q38031309)

27 August 2017

title

Novel stem cell-based drug discovery platforms for cardiovascular disease (English)

1 reference

27 August 2017

1 reference

William J Adams

1

1 reference

27 August 2017

Guillermo García-Cardeña

series ordinal

2

1 reference

27 August 2017

publication date

1 August 2012

1 reference

Journal of Biomolecular Screening

27 August 2017

published in

1 reference

27 August 2017

volume

17

1 reference

27 August 2017

issue

9

1 reference

27 August 2017

page(s)

1117-1127

1 reference

How were new medicines discovered?

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Diagnosing the decline in pharmaceutical R&D efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The productivity crisis in pharmaceutical R&D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Heart disease and stroke statistics--2012 update: a report from the American Heart Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Personalized cardiovascular medicine and drug development: time for a new paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

A network view of disease and compound screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Genomewide association analysis of coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The extracellular matrix as a cell survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Geometric control of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Mechanotransduction across the cell surface and through the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial/pericyte interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Complex phenotypic assays in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The application of phenotypic high-throughput screening techniques to cardiovascular research

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Finding new hits in neglected disease projects: target or phenotypic based screening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The promise of induced pluripotent stem cells in research and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Hematopoietic and endothelial differentiation of human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Three-dimensional growth of iPS cell-derived smooth muscle cells on nanofibrous scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Neutrophil differentiation from human-induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Genetic engineering of human pluripotent cells using TALE nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Phenotype and course of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Cellular mechanotransduction: putting all the pieces together again

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Mechanotransduction in vascular physiology and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Role of integrins in endothelial mechanosensing of shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Soft lithography in biology and biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Computer-controlled microcirculatory support system for endothelial cell culture and shearing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Well plate-coupled microfluidic devices designed for facile image-based cell adhesion and transmigration assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Chronic kidney disease: effects on the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Genetic causes of vascular malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Regulation of vascular calcification: roles of phosphate and osteopontin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial-pericyte interactions in angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Leukocyte adhesion in the liver: distinct adhesion paradigm from other organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

How do mesangial and endothelial cells form the glomerular tuft?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Astrocyte-endothelial interactions at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial dysfunction: a marker of atherosclerotic risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial dysfunction in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Cerebral cavernous malformation: new molecular and clinical insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Development of a computer-assisted high-throughput screening platform for anti-angiogenic testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Mechanisms of transendothelial migration of leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The physiology of leukocyte recruitment: an in vivo perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Immune and inflammatory mechanisms of atherosclerosis (*)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Biomechanics of cell interactions in shear fields

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Signaling mechanisms regulating endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Advanced glycation end products: sparking the development of diabetic vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

A microfluidic chip for permeability assays of endothelial monolayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

Vascular biology in uremia: insights into novel mechanisms of vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

A new grammar for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112454741

21 January 2018

Identifiers

DOI

10.1177/1087057112454741

1 reference

27 August 2017

1 reference