(Q38035437)

27 August 2017

title

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems (English)

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27 August 2017

Stefan Tümpel

1

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27 August 2017

K Lenhard Rudolph

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

1 August 2012

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Annals of the New York Academy of Sciences

27 August 2017

published in

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27 August 2017

volume

1266

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27 August 2017

page(s)

28-39

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Protein composition of catalytically active human telomerase from immortal cells

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The many facets of H/ACA ribonucleoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

TCAB1: driving telomerase to Cajal bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere maintenance in human B lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Cellular senescence as a tumor-protection mechanism: the essential role of counting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase mutations in families with idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A spectrum of severe familial liver disorders associate with telomerase mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase gene mutations are associated with cirrhosis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Constitutional telomerase mutations are genetic risk factors for cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Recent progress in dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Dyskeratosis congenita, stem cells and telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Stem cells, ageing and the quest for immortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Developmental and tissue-specific regulation of mouse telomerase and telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere length is a determinant of emphysema susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Constitutive telomerase expression promotes mammary carcinomas in aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere length is inherited with resetting of the telomere set-point.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction induces metabolic and mitochondrial compromise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short telomeres compromise β-cell signaling and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Conditional telomerase induction causes proliferation of hair follicle stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

TERT promotes cellular and organismal survival independently of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase modulates Wnt signalling by association with target gene chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short telomeres, even in the presence of telomerase, limit tissue renewal capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Wild-derived inbred mouse strains have short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short telomeres are sufficient to cause the degenerative defects associated with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The role of stem cells in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Hematopoietic stem cell aging: mechanism and consequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Immunoaging induced by hematopoietic stem cell aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere biology in hematopoiesis and stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The two-stage mechanism controlling cellular senescence and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

End Resection Initiates Genomic Instability in the Absence of Telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

ATM and ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Replicative aging, telomeres, and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

DNA damage checkpoint kinase Chk2 triggers replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The hematopoietic stem cell in its place

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Oxidative stress shortens telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Accelerated telomere shortening in Fanconi anemia fibroblasts--a longitudinal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

The role of estrogen deficiency in skin ageing and wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2012.06547.X

10.1111/J.1749-6632.2012.06547.X

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference