(Q38036825)

English

Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs.

scientific article published on 23 August 2012

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22914253%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22914253%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Melisa Gualdrón-López

1

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Europe PubMed Central

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11 February 2020

Paul A.M. Michels

4

1 reference

Europe PubMed Central

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11 February 2020

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Ana Brennand

2

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Europe PubMed Central

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11 February 2020

Luisana Avilán

3

1 reference

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11 February 2020

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23 August 2012

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11 February 2020

1 reference

Europe PubMed Central

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11 February 2020

140

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11 February 2020

1

1 reference

Europe PubMed Central

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11 February 2020

1-20

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Europe PubMed Central

PubMed publication ID

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11 February 2020

When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glucose is toxic to glycosome-deficient trypanosomes.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

A proteomic analysis of arsenical drug resistance in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Import of assembled PTS1 proteins into peroxisomes of the yeast Hansenula polymorpha: yes and no!

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Structure, function, and biogenesis of glycosomes in kinetoplastida

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

A domino effect in drug action: from metabolic assault towards parasite differentiation.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Implications of the dominant role of transporters in drug uptake by cells

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Peroxin 5: a cycling receptor for protein translocation into peroxisomes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Metabolite transport across the peroxisomal membrane

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glycolysis as a target for the design of new anti-trypanosome drugs.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

PTS2 co-receptors: diverse proteins with common features

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: Identification, expression and subcellular localisation.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Characterization of carbohydrate metabolism and demonstration of glycosomes in a Phytomonas sp. isolated from Euphorbia characias

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Protein import machineries of peroxisomes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glucose metabolism and the channeling of glycolytic intermediates in permeabilized L-929 cells

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Interaction between D-glyceraldehyde-3-phosphate dehydrogenase and calmodulin.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Old pathway--new concept: control of glycolysis by metabolite-modulated dynamic enzyme associations

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Peroxisome targeting signal 1: is it really a simple tripeptide?

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Enzymes of carbohydrate metabolism as potential drug targets.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei : The glycosome

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Biochemical peculiarities of trypanosomes, African and South American

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Intracellular growth and pathogenesis of Leishmania parasites

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Compartmentation protects trypanosomes from the dangerous design of glycolysis

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Peroxisomal ABC transporters: structure, function and role in disease

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

The molecular basis of substrate channeling

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Metabolic functions of glycosomes in trypanosomatids

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

An oligomeric protein is imported into peroxisomes in vivo

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Reversible transdominant inhibition of a metabolic pathway. In vivo evidence of interaction between two sequential tricarboxylic acid cycle enzymes in yeast

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

PTS1-independent sorting of peroxisomal matrix proteins by Pex5p

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Peroxisomal ABC transporters

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Analysis of glycolytic enzyme co-localization in Drosophila flight muscle

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Dynamic architecture of the peroxisomal import receptor Pex5p

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Metabolic pathways required for the intracellular survival of Leishmania

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glucose metabolism in Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Uniqueness of the mechanism of protein import into the peroxisome matrix: transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

The import receptor Pex7p and the PTS2 targeting sequence

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Metabolon formation and metabolic channeling in the biosynthesis of plant natural products

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm)

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

The rat liver peroxisomal membrane forms a permeability barrier for cofactors but not for small metabolites in vitro

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

An involvement of yeast peroxisomal channels in transmembrane transfer of glyoxylate cycle intermediates

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Transfer of metabolites across the peroxisomal membrane

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Absence of substrate channeling in the glycosome of Trypanosoma brucei.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Solute traffic across mammalian peroxisomal membrane – single channel conductance monitoring reveals pore-forming activities in peroxisomes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Demonstration of glycosomes (microbodies) in the bodonid flagellate Trypanoplasma borelli (protozoa, kinetoplastida)

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Synthesis and activity of inhibitors highly specific for the glycolytic enzymes from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

21 January 2018

Strategies to optimize the brain availability of central nervous system drug candidates

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific characteristics of phosphofructokinase-microtubule interaction.

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Subcellular localization of some glycolytic enzymes in parasitic flagellated protozoa

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Complexes of sequential metabolic enzymes

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxisomal protein import and ERAD: variations on a common theme

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

The structural properties of plant peroxisomes and their metabolic significance

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of glycosomes and metabolic end products in pathogenic and nonpathogenic strains of Cryptobia salmositica (Kinetoplastida: Bodonidae)

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein transport across the peroxisomal membrane

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid metabolism in peroxisomes in relation to human disease

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell permeation of a Trypanosoma brucei aldolase inhibitor: evaluation of different enzyme-labile phosphate protecting groups

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

The peroxisomal importomer constitutes a large and highly dynamic pore

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

High-throughput decoding of antitrypanosomal drug efficacy and resistance

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Does the proteome encode organellar pH?

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxisomal matrix protein import: the transient pore model

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0031182012001278

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1017/S0031182012001278

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22914253%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22914253%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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