(Q38038539)

27 August 2017

title

Trial designs used to study neuroprotective therapy in Parkinson's disease (English)

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27 August 2017

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Werner Poewe

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Olivier Rascol

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Anthony E Lang

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27 August 2017

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Eldad Melamed

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27 August 2017

language of work or name

English

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publication date

23 August 2012

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27 August 2017

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27 August 2017

volume

28

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issue

1

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27 August 2017

page(s)

86-95

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Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future

27 August 2017

cites work

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Defining disease‐modifying therapies for PD—A road map for moving forward

21 January 2018

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Timing of treatment initiation in Parkinson's disease: a need for reappraisal?

21 January 2018

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Interpreting the results of Parkinson's disease clinical trials: time for a change

21 January 2018

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Benign tremulous parkinsonism

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Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening

21 January 2018

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

21 January 2018

1 reference

TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial

21 January 2018

1 reference

The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations

21 January 2018

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The clinically important difference on the unified Parkinson's disease rating scale.

21 January 2018

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UPDRS activity of daily living score as a marker of Parkinson's disease progression

21 January 2018

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Comparative responsiveness of Parkinson's disease scales to change over time.

21 January 2018

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A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

21 January 2018

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The effect of deprenyl and levodopa on the progression of Parkinson's disease

21 January 2018

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Levodopa and the progression of Parkinson's disease

21 January 2018

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Washout and delayed start designs for identifying disease modifying effects in slowly progressive diseases using disease progression analysis

21 January 2018

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A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): rationale, design, and baseline characteristics

21 January 2018

1 reference

A double-blind, delayed-start trial of rasagiline in Parkinson's disease

21 January 2018

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A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

21 January 2018

1 reference

Rationale for delayed-start study of pramipexole in Parkinson's disease: the PROUD study

21 January 2018

1 reference

Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study

21 January 2018

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Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.

21 January 2018

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Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease

21 January 2018

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"Disease-modification" trials in Parkinson disease: target populations, endpoints and study design

21 January 2018

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A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

21 January 2018

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A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

21 January 2018

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Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

21 January 2018

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The progression of pathology in longitudinally followed patients with Parkinson's disease.

21 January 2018

1 reference

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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Missing pieces in the Parkinson's disease puzzle

21 January 2018

1 reference

The progression of Parkinson disease: a hypothesis

21 January 2018

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

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A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

21 January 2018

1 reference

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

21 January 2018

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Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.24997

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27 August 2017

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