(Q38038561)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Lysosome-dependent pathways as a unifying theme in Parkinson's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

George K Tofaris

series ordinal

1

1 reference

27 August 2017

language of work or name

English

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publication date

23 August 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

27

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

1364-1369

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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Alpha-synuclein in Lewy bodies

21 January 2018

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Young-onset Parkinson's disease revisited--clinical features, natural history, and mortality

21 January 2018

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A multidisciplinary study of patients with early-onset PD with and without parkin mutations

21 January 2018

1 reference

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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PINK1-linked parkinsonism is associated with Lewy body pathology.

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

21 January 2018

1 reference

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

Genomic investigation of alpha-synuclein multiplication and parkinsonism

21 January 2018

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

21 January 2018

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Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.

21 January 2018

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Association of glucocerebrosidase mutations with dementia with lewy bodies

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

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DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

21 January 2018

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

1 reference

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

21 January 2018

1 reference

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

21 January 2018

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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

21 January 2018

1 reference

α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies

21 January 2018

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Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons

21 January 2018

1 reference

Physiological and pathological properties of alpha-synuclein

21 January 2018

1 reference

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

1 reference

SNCA variant associated with Parkinson disease and plasma alpha-synuclein level

21 January 2018

1 reference

The ups and downs of alpha-synuclein mRNA expression.

21 January 2018

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alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

21 January 2018

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Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

21 January 2018

1 reference

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

21 January 2018

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

21 January 2018

1 reference

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

1 reference

VPS35 mutations in Parkinson disease

21 January 2018

1 reference

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

21 January 2018

1 reference

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

21 January 2018

1 reference

Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

21 January 2018

1 reference

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

21 January 2018

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Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

21 January 2018

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Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

21 January 2018

1 reference

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

1 reference

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

21 January 2018

1 reference

Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

1 reference

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

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Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis

21 January 2018

1 reference

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

21 January 2018

1 reference

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

1 reference

Pathogenic lysosomal depletion in Parkinson's disease

21 January 2018

1 reference

Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies

21 January 2018

1 reference

Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

1 reference

Neuropathology provides clues to the pathophysiology of Gaucher disease

21 January 2018

1 reference

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease

21 January 2018

1 reference

Neuronal and glial accumulation of alpha- and beta-synucleins in human lipidoses

21 January 2018

1 reference

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

21 January 2018

1 reference

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MDS.25136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927213%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference