(Q38040282)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Ayse Ulusoy

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

1 reference

4 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

published in

Molecular Neurobiology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

47

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

484-494

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

Friedrich Heinrich Lewy (1885-1950) and his work

12 February 2020

cites work

1 reference

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A brief history of levodopa

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

1 reference

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

21 January 2018

1 reference

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Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease

21 January 2018

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Synucleinopathies: clinical and pathological implications

21 January 2018

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

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A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

21 January 2018

1 reference

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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

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Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

21 January 2018

1 reference

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Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Genomic investigation of alpha-synuclein multiplication and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Rotenone, paraquat, and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Head trauma preceding PD: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Head injury, α-synuclein Rep1, and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Age-dependent synuclein pathology following traumatic brain injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Decreased alpha-synuclein expression in the aging mouse substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

In vivo silencing of alpha-synuclein using naked siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Olfactory deficits in mice overexpressing human wildtype alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Use of viral vectors to create animal models for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8329-Y

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

21 January 2018

1 reference

12 December 2020

Aggregation of alpha-synuclein/NACP in the neuronal and glial cells in diffuse Lewy body disease: a survey of six patients.

1 reference

12 December 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

12 December 2020

α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

1 reference

12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

1 reference

12 December 2020

Neuropathology in mice expressing human alpha-synuclein

1 reference

12 December 2020

10.1007/S12035-012-8329-Y

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 February 2020

1028667165

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22944910%20AND%20SRC:MED&resulttype=core&format=json