(Q38043290)

27 August 2017

title

The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation (English)

1 reference

27 August 2017

Heather Knowles

1

1 reference

27 August 2017

Yuan Li

series ordinal

2

1 reference

27 August 2017

Anne-Laure Perraud

series ordinal

3

1 reference

27 August 2017

publication date

1 March 2013

1 reference

27 August 2017

1 reference

27 August 2017

volume

55

1 reference

27 August 2017

issue

1-3

1 reference

27 August 2017

page(s)

241-248

1 reference

https://scigraph.springernature.com/pub.10.1007/s12026-012-8373-8

27 August 2017

exact match

0 references

cites work

TRP channels: an overview

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRP channels as cellular sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 Ca2+ permeable cation channels: from gene to biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Evolutionary determinants of divergent calcium selectivity of TRPM channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The Nudix hydrolase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Emerging roles of NAD+ and its metabolites in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

CD38 plays a dual role in allergen-induced airway hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Immunocyte Ca2+ influx system mediated by LTRPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of TRPM2 by extra- and intracellular calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Regulation of the antimicrobial response by NLR proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 Ca2+ channel regulates energy balance and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Role and regulation of TRP channels in neutrophil granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Calcium, ischemia and excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential channels of the melastatin family and ischemic responses of central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Transient receptor potential melastatin 2 expression is increased following experimental traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Gender and the injured brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

21 January 2018

TRP channels of islets.

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Roles of TRPM2 in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8373-8

Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes

21 January 2018

1 reference

12 December 2020

Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels

1 reference

12 December 2020

Transient receptor potential cation channels in pancreatic β cells

1 reference

12 December 2020

Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures

1 reference

12 December 2020

Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death

1 reference

12 December 2020

Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta

1 reference

12 December 2020

Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP.

1 reference

12 December 2020

Targeting ion channels for drug discovery.

1 reference

12 December 2020

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

1 reference

12 December 2020

10.1007/S12026-012-8373-8

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1025937097

0 references

1 reference