(Q38049175)

27 August 2017

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies (English)

1 reference

27 August 2017

2

1 reference

27 August 2017

Jacques Fahy

1

1 reference

PubMed ID

23033952

27 August 2017

Paola B Arimondo

series ordinal

3

1 reference

PubMed ID

23033952

27 August 2017

language of work or name

English

0 references

publication date

3 October 2012

1 reference

Expert Opinion on Therapeutic Patents

27 August 2017

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27 August 2017

22

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27 August 2017

12

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27 August 2017

1427-1442

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Crystal structure of the nucleosome core particle at 2.8 A resolution

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Chromatin structure and the inheritance of epigenetic information

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Epigenetic reprogramming in plant and animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Molecular signals of epigenetic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

An operational definition of epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Perceptions of epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Stability and flexibility of epigenetic gene regulation in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Structure and function of mammalian DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

The role of methyl-binding proteins in chromatin organization and epigenome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

The epigenetic progenitor origin of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Targeting DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Role of human nucleoside transporters in the uptake and cytotoxicity of azacitidine and decitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Potential antitumor agents. 29. Quantitative structure-activity relationships for the antileukemic bisquaternary ammonium heterocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Discovery of two novel, small-molecule inhibitors of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Identification of novel DNA methylation inhibitors via a two-component reporter gene system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Curcumin is a potent DNA hypomethylation agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Hydralazine target: from blood vessels to the epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.729579

10.1517/13543776.2012.729579

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

23033952