(Q38056148)

27 August 2017

Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms (English)

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Mycobacterium tuberculosis

27 August 2017

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author name string

Rajesh Jayachandran

series ordinal

1

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PubMed ID

23106276

27 August 2017

Nicole Scherr

series ordinal

2

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PubMed ID

23106276

27 August 2017

Jean Pieters

series ordinal

3

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27 August 2017

1 September 2012

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Expert Review of Anti-infective Therapy

27 August 2017

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27 August 2017

10

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27 August 2017

9

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27 August 2017

1007-1022

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The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis

27 August 2017

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Bacterial growth and cell division: a mycobacterial perspective

21 January 2018

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Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

21 January 2018

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Neutrophils and intracellular pathogens: beyond phagocytosis and killing

21 January 2018

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Cell-mediated immune responses in tuberculosis

21 January 2018

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The secret lives of the pathogenic mycobacteria

21 January 2018

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Mycobacterium tuberculosis: success through dormancy

21 January 2018

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Mycobacterium tuberculosis and the macrophage: maintaining a balance.

21 January 2018

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Neutrophils from Mycobacterium avium-infected mice produce TNF-alpha, IL-12, and IL-1 beta and have a putative role in early host response

21 January 2018

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Induction of apoptosis in human neutrophils by Mycobacterium tuberculosis is dependent on mature bacterial lipoproteins.

21 January 2018

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Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.

21 January 2018

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Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis

21 January 2018

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Neutrophil-mediated innate immune resistance to mycobacteria

21 January 2018

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Lack of fusion of azurophil granules with phagosomes during phagocytosis of Mycobacterium smegmatis by human neutrophils is not actively controlled by the bacterium

21 January 2018

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Mechanisms of phagocytosis in macrophages

21 January 2018

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Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process

21 January 2018

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A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance

21 January 2018

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Complement levels and activity in the normal and LPS-injured lung

21 January 2018

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Nonopsonic phagocytosis of zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) involves distinct molecular determinants and is or is not coupled with NADPH oxidase activation

21 January 2018

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Essential role for cholesterol in entry of mycobacteria into macrophages

21 January 2018

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Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells.

21 January 2018

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Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

21 January 2018

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Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice

21 January 2018

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Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon

21 January 2018

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The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA

21 January 2018

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Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine–threonine kinases PknA and PknB

21 January 2018

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Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B

21 January 2018

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Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

21 January 2018

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MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity

21 January 2018

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Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice

21 January 2018

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Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

21 January 2018

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Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages

21 January 2018

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

21 January 2018

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Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

21 January 2018

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Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

21 January 2018

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Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

21 January 2018

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Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

21 January 2018

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Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).

21 January 2018

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Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB

21 January 2018

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PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis

21 January 2018

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The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

21 January 2018

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Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases

21 January 2018

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Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis

21 January 2018

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The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages

21 January 2018

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The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

21 January 2018

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Interdomain interaction reconstitutes the functionality of PknA, a eukaryotic type Ser/Thr kinase from Mycobacterium tuberculosis.

21 January 2018

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Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis

21 January 2018

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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

21 January 2018

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Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria

21 January 2018

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Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis.

21 January 2018

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Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival

21 January 2018

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PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity

21 January 2018

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The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue

21 January 2018

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Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis

21 January 2018

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Retracted: Novel Role of Phosphorylation-Dependent Interaction between FtsZ and FipA in Mycobacterial Cell Division

21 January 2018

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Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis

21 January 2018

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The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division

21 January 2018

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A pseudokinase debut at the mycobacterial cell wall

21 January 2018

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A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

21 January 2018

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The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization

21 January 2018

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Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

21 January 2018

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Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

21 January 2018

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Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis

21 January 2018

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Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis

21 January 2018

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Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis

21 January 2018

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Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG.

21 January 2018

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Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

21 January 2018

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Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria.

21 January 2018

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Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis

21 January 2018

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Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host

21 January 2018

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Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G

21 January 2018

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A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

21 January 2018

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Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis

21 January 2018

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Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice

21 January 2018

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Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis

21 January 2018

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EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR

21 January 2018

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Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation

21 January 2018

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The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

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Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis

21 January 2018

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Delivering proteins for export from the cytosol

21 January 2018

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Protein secretion systems in Mycobacteria.

21 January 2018

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SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis

21 January 2018

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The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response

21 January 2018

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The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages.

21 January 2018

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The ins and outs of Mycobacterium tuberculosis protein export

21 January 2018

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ESX/type VII secretion systems and their role in host-pathogen interaction

21 January 2018

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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue

21 January 2018

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ESAT-6 proteins: protective antigens and virulence factors?

21 January 2018

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Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium

21 January 2018

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Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?

21 January 2018

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Regulated proteolysis in Gram-negative bacteria--how and when?

21 January 2018

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The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease

21 January 2018

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Inhibitors selective for mycobacterial versus human proteasomes

21 January 2018

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The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

21 January 2018

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Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence

21 January 2018

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Mycobacterium tuberculosis prevents inflammasome activation

21 January 2018

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cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria.

21 January 2018

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Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

21 January 2018

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Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif

21 January 2018

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A coat protein on phagosomes involved in the intracellular survival of mycobacteria

21 January 2018

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The ancient regulatory-protein family of WD-repeat proteins

21 January 2018

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The WD repeat: a common architecture for diverse functions

21 January 2018

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RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes

21 January 2018

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Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages

21 January 2018

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Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis.

21 January 2018

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Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering.

21 January 2018

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Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin

21 January 2018

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Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune responses in vivo

21 January 2018

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Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages

21 January 2018

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Calcium signalling in lymphocytes.

21 January 2018

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Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

21 January 2018

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The interferon-inducible GTPases.

21 January 2018

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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

21 January 2018

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Human IRGM induces autophagy to eliminate intracellular mycobacteria

21 January 2018

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Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase

21 January 2018

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A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection

21 January 2018

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Voltage gated calcium channels negatively regulate protective immunity to Mycobacterium tuberculosis

21 January 2018

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International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels

21 January 2018

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Overview of molecular relationships in the voltage-gated ion channel superfamily.

21 January 2018

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Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.

21 January 2018

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Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification

21 January 2018

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Endosomal and non-endosomal functions of ESCRT proteins

21 January 2018

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ESCRT factors restrict mycobacterial growth

21 January 2018

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Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen

21 January 2018

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

21 January 2018

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Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

21 January 2018

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Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

21 January 2018

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TB drug discovery: addressing issues of persistence and resistance

21 January 2018

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Immunological control of tuberculosis: role of tumour necrosis factor and more

21 January 2018

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Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

21 January 2018

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Innate immune recognition of Mycobacterium tuberculosis

21 January 2018

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A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

21 January 2018

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Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

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Toll-like receptor pathways in the immune responses to mycobacteria

21 January 2018

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Cellular responses to interferon-gamma

21 January 2018

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IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

21 January 2018

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

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Regulation of phagosome maturation by signals from toll-like receptors

21 January 2018

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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

21 January 2018

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The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria

21 January 2018

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Lipid lunch for persistent pathogen

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERI.12.95

1 reference

27 August 2017

1 reference

PubMed ID

23106276