(Q38061186)

28 August 2017

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title

The genetics of type 2 diabetes and its clinical relevance (English)

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28 August 2017

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A Pal

1

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PubMed ID

23167659

28 August 2017

M I McCarthy

series ordinal

2

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28 August 2017

4 December 2012

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28 August 2017

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28 August 2017

83

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28 August 2017

297-306

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28 August 2017

4

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

28 August 2017

1 reference

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

21 January 2018

1 reference

The future of genetic studies of complex human diseases

21 January 2018

1 reference

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

1 reference

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

1 reference

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

1 reference

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

1 reference

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

1 reference

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

21 January 2018

1 reference

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

21 January 2018

1 reference

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

21 January 2018

1 reference

A genome-wide association search for type 2 diabetes genes in African Americans

21 January 2018

1 reference

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

21 January 2018

1 reference

Genome-wide association studies provide new insights into type 2 diabetes aetiology

21 January 2018

1 reference

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

21 January 2018

1 reference

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

21 January 2018

1 reference

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

1 reference

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

21 January 2018

1 reference

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

1 reference

Variants in MTNR1B influence fasting glucose levels

21 January 2018

1 reference

Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention

21 January 2018

1 reference

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

21 January 2018

1 reference

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease

21 January 2018

1 reference

Type 2 diabetes risk alleles are associated with reduced size at birth

21 January 2018

1 reference

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

21 January 2018

1 reference

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from

21 January 2018

1 reference

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

1 reference

A map of open chromatin in human pancreatic islets

21 January 2018

1 reference

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

21 January 2018

1 reference

Wnt signaling regulates pancreatic beta cell proliferation

21 January 2018

1 reference

Cancer as an endocrine problem

21 January 2018

1 reference

Multiple loci identified in a genome-wide association study of prostate cancer

21 January 2018

1 reference

The regulation of INK4/ARF in cancer and aging

21 January 2018

1 reference

p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

1 reference

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

21 January 2018

1 reference

Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations

21 January 2018

1 reference

Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.

21 January 2018

1 reference

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

21 January 2018

1 reference

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

21 January 2018

1 reference

Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young

21 January 2018

1 reference

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein

21 January 2018

1 reference

Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations

21 January 2018

1 reference

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

21 January 2018

1 reference

21 January 2018

1 reference

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity

21 January 2018

1 reference

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

21 January 2018

1 reference

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

21 January 2018

1 reference

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

21 January 2018

1 reference

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

21 January 2018

1 reference

XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients

21 January 2018

1 reference

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

1 reference

The clinical application of genetic testing in type 2 diabetes: a patient and physician survey

21 January 2018

1 reference

Genotype score in addition to common risk factors for prediction of type 2 diabetes

21 January 2018

1 reference

Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

1 reference

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

21 January 2018

1 reference

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

21 January 2018

1 reference

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

21 January 2018

1 reference

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

21 January 2018

1 reference

Principles in genetic risk assessment

21 January 2018

1 reference

Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy

21 January 2018

1 reference

Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection

21 January 2018

1 reference

Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes

21 January 2018

1 reference

An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes

21 January 2018

1 reference

Genetic associations in diabetic nephropathy: a meta-analysis

21 January 2018

1 reference

Tamm-Horsfall glycoprotein: biology and clinical relevance

21 January 2018

1 reference

Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases

21 January 2018

1 reference

Multiple loci associated with indices of renal function and chronic kidney disease

21 January 2018

1 reference

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

21 January 2018

1 reference

Genetic cause of hyperglycaemia and response to treatment in diabetes

21 January 2018

1 reference

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

21 January 2018

1 reference

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

1 reference

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

21 January 2018

1 reference

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

1 reference

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

21 January 2018

1 reference

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

1 reference

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

21 January 2018

1 reference

Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

21 January 2018

1 reference

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

21 January 2018

1 reference

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel

21 January 2018

1 reference

Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes

21 January 2018

1 reference

Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma2 gene on rosiglitazone response in type 2 diabetes

21 January 2018

1 reference

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of

21 January 2018

1 reference

Sequence variation in PPARG may underlie differential response to troglitazone

21 January 2018

1 reference

Clan genomics and the complex architecture of human disease

21 January 2018

1 reference

Recent explosive human population growth has resulted in an excess of rare genetic variants

21 January 2018

1 reference

The mystery of missing heritability: Genetic interactions create phantom heritability

21 January 2018

1 reference

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

21 January 2018

1 reference

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

21 January 2018

1 reference

Uromodulin gene variant is associated with type 2 diabetic nephropathy

21 January 2018

1 reference

Immature Renal Structures Associated With a Novel UMOD Sequence Variant

21 January 2018

1 reference

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/CGE.12055

1 reference

28 August 2017

1 reference

PubMed ID

23167659