(Q38061869)

28 August 2017

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title

The many facets of MLL1 regulation (English)

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28 August 2017

2

Elisa Bergamin

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28 August 2017

Pamela Zhang

1

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28 August 2017

Jean-François Couture

series ordinal

3

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28 August 2017

publication date

1 February 2013

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28 August 2017

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28 August 2017

volume

99

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28 August 2017

issue

2

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28 August 2017

page(s)

136-145

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Regulation of chromatin by histone modifications

28 August 2017

cites work

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Chromatin modifications and their function

21 January 2018

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Epigenetic modifications in cancer

21 January 2018

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Roles of the Polycomb group proteins in stem cells and cancer

21 January 2018

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Histone onco-modifications

21 January 2018

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MLL targets SET domain methyltransferase activity to Hox gene promoters

21 January 2018

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Structural insight into histone recognition by the ING PHD fingers

21 January 2018

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PHD fingers: epigenetic effectors and potential drug targets

21 January 2018

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The SET-domain protein superfamily: protein lysine methyltransferases

21 January 2018

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Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae

21 January 2018

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A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

21 January 2018

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COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

21 January 2018

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The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4

21 January 2018

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COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression

21 January 2018

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Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression

21 January 2018

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Structural and biochemical insights into MLL1 core complex assembly

21 January 2018

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Regulation of MLL1 H3K4 methyltransferase activity by its core components

21 January 2018

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Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1

21 January 2018

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BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro

21 January 2018

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Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation

21 January 2018

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Wdr5 is essential for osteoblast differentiation

21 January 2018

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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

21 January 2018

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Structural basis for molecular recognition and presentation of histone H3 by WDR5

21 January 2018

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Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

21 January 2018

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Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

21 January 2018

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Molecular recognition of histone H3 by the WD40 protein WDR5.

21 January 2018

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Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

21 January 2018

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Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

21 January 2018

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WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket

21 January 2018

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The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

21 January 2018

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An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain

21 January 2018

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A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex

21 January 2018

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Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex

21 January 2018

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WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2.

21 January 2018

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WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation

21 January 2018

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Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network

21 January 2018

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

21 January 2018

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Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression

21 January 2018

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Ash2l interacts with Tbx1 and is required during early embryogenesis

21 January 2018

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Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30

21 January 2018

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p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation

21 January 2018

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Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.

21 January 2018

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Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

21 January 2018

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Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription

21 January 2018

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NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters

21 January 2018

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Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

21 January 2018

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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

21 January 2018

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Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains

21 January 2018

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On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex

21 January 2018

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Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

21 January 2018

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Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks

21 January 2018

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Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human

21 January 2018

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Positional cloning of the gene for multiple endocrine neoplasia-type 1

21 January 2018

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Functional studies of the MEN1 gene

21 January 2018

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Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.

21 January 2018

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Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

21 January 2018

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The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

21 January 2018

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Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

21 January 2018

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The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

21 January 2018

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Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein

21 January 2018

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

21 January 2018

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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

21 January 2018

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The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

21 January 2018

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 January 2018

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The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

21 January 2018

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A nuclear RNA-binding cyclophilin in human T cells

21 January 2018

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Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

21 January 2018

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The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression,

21 January 2018

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MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

21 January 2018

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Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization

21 January 2018

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Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain

21 January 2018

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Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 January 2018

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

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Long noncoding RNA as modular scaffold of histone modification complexes

21 January 2018

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Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax

21 January 2018

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The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin

21 January 2018

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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.22126

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28 August 2017

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