(Q38062280)

28 August 2017

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title

Regulation of fungal secondary metabolism (English)

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28 August 2017

Axel A Brakhage

1

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28 August 2017

language of work or name

English

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publication date

26 November 2012

1 reference

Nature Reviews Microbiology

28 August 2017

published in

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28 August 2017

volume

11

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28 August 2017

issue

1

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28 August 2017

page(s)

21-32

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https://scigraph.springernature.com/pub.10.1038/nrmicro2916

28 August 2017

exact match

0 references

cites work

Bioactive microbial metabolites

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Effect of competition on the production and activity of secondary metabolites inAspergillusspecies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Antibiotics as signalling molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Fungal secondary metabolites - strategies to activate silent gene clusters

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Natural products of filamentous fungi: enzymes, genes, and their regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Biosynthesis and function of gliotoxin in Aspergillus fumigatus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The biosynthetic logic of polyketide diversity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Nonribosomal peptide synthetases: structures and dynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

New insights into the formation of fungal aromatic polyketides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The ergot alkaloid gene cluster: functional analyses and evolutionary aspects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Aspergillus has distinct fatty acid synthases for primary and secondary metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Hidden biosynthetic treasures brought to light

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

SMURF: Genomic mapping of fungal secondary metabolite clusters

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

FungiFun: a web-based application for functional categorization of fungal genes and proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Transcriptional regulatory elements in fungal secondary metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Transcription factors in fungi.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Three binding sites for the Aspergillus nidulans PacC zinc-finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The penicillin regulator PENR1 of Aspergillus nidulans is a HAP-like transcriptional complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Secondary metabolism: regulation and role in fungal biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A complex ergovaline gene cluster in epichloe endophytes of grasses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The ergot alkaloid gene cluster in Claviceps purpurea: extension of the cluster sequence and intra species evolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Molecular cloning and genetic analysis of a symbiosis-expressed gene cluster for lolitrem biosynthesis from a mutualistic endophyte of perennial ryegrass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Characterization of the Aspergillus nidulans monodictyphenone gene cluster.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Sub-telomere directed gene expression during initiation of invasive aspergillosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Genetic regulation of aflatoxin biosynthesis: from gene to genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Secondary metabolic gene cluster silencing in Aspergillus nidulans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Chromosomal location plays a role in regulation of aflatoxin gene expression in Aspergillus parasiticus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

pH Regulation of Sterigmatocystin and Aflatoxin Biosynthesis in Aspergillus spp

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The thioredoxin system of Penicillium chrysogenum and its possible role in penicillin biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Evidence for an ergot alkaloid gene cluster in Claviceps purpurea

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Role of AREA, a regulator of nitrogen metabolism, during colonization of maize kernels and fumonisin biosynthesis in Fusarium verticillioides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Identification of a minimal cre1 promoter sequence promoting glucose-dependent gene expression in the beta-lactam producer Acremonium chrysogenum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Loss of glucose repression in an Acremonium chrysogenum β-lactam producer strain and its restoration by multiple copies of the cre1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The fungal CPCR1 protein, which binds specifically to beta-lactam biosynthesis genes, is related to human regulatory factor X transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

CPCR1, but not its interacting transcription factor AcFKH1, controls fungal arthrospore formation in Acremonium chrysogenum.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

LaeA, a regulator of secondary metabolism in Aspergillus spp

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Histone deacetylase activity regulates chemical diversity in Aspergillus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Regulation of secondary metabolism by chromatin structure and epigenetic codes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Telomeres in the rice blast fungus Magnaporthe oryzae: the world of the end as we know it.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Chromatin-level regulation of biosynthetic gene clusters

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Pathogen-mediated posttranslational modifications: A re-emerging field

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Isolation of a sexual sporulation hormone from Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A homologue of the Aspergillus velvet gene regulates both cephalosporin C biosynthesis and hyphal fragmentation in Acremonium chrysogenum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

ChLae1 and ChVel1 regulate T-toxin production, virulence, oxidative stress response, and development of the maize pathogen Cochliobolus heterostrophus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Epigenetic remodeling of the fungal secondary metabolome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2916

Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus.

31 March 2020

1 reference

12 December 2020

Genomic mining for Aspergillus natural products

1 reference

12 December 2020

FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence

1 reference

12 December 2020

The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR.

1 reference

12 December 2020

Isolation, characterization and disruption of the areA nitrogen regulatory gene of Gibberella fujikuroi

1 reference

12 December 2020

Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC.

1 reference

12 December 2020

Molecular regulation of beta-lactam biosynthesis in filamentous fungi

1 reference

12 December 2020

Regulation of cephalosporin biosynthesis.

1 reference

12 December 2020

Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved early in the aflatoxin pathway

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRMICRO2916

1 reference

Dimensions Publication ID

28 August 2017

1049435324

0 references

1 reference