(Q38065073)

28 August 2017

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title

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses (English)

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28 August 2017

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E Elinav

1

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28 August 2017

J Henao-Mejia

series ordinal

2

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28 August 2017

R A Flavell

series ordinal

3

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28 August 2017

language of work or name

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5 December 2012

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28 August 2017

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28 August 2017

6

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28 August 2017

1

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28 August 2017

4-13

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https://scigraph.springernature.com/pub.10.1038/mi.2012.115

28 August 2017

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cites work

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Inflammasomes in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Sensing and reacting to microbes through the inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Differential requirements for NAIP5 in activation of the NLRC4 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Role of inflammasomes in host defense against Citrobacter rodentium infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Non-canonical inflammasome activation targets caspase-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Interleukin-18 in intestinal inflammation: friend and foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Inflammasomes: far beyond inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Linkage of gut microbiome with cognition in hepatic encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Mouse models for the study of colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

IL18 polymorphism is associated with an increased risk of Crohn's disease.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

1 reference

https://api.crossref.org/works/10.1038%2FMI.2012.115

7 January 2021

Identifiers

DOI

10.1038/MI.2012.115

1 reference

Dimensions Publication ID

28 August 2017

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