(Q38071001)

28 August 2017

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title

An introduction to hybrid ion trap/time-of-flight mass spectrometry coupled with liquid chromatography applied to drug metabolism studies (English)

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28 August 2017

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Zhao-Ying Liu

1

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28 August 2017

publication date

1 December 2012

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Journal of Mass Spectrometry

28 August 2017

published in

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28 August 2017

volume

47

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28 August 2017

issue

12

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28 August 2017

page(s)

1627-1642

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Strategies for dealing with metabolite elucidation in drug discovery and development

28 August 2017

cites work

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Recent development in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification

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Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry

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In vitro metabolism of ethoxidine by human CYP1A1 and rat microsomes: identification of metabolites by high-performance liquid chromatography combined with electrospray tandem mass spectrometry and accurate mass measurements by time-of-flight mass s

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Application of atmospheric pressure ionization time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites.

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Discovering metabolites of post-harvest fungicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap tandem mass spectrometry

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Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements

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An introduction to quadrupole-time-of-flight mass spectrometry

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Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds

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Metabolomics applications of FT-ICR mass spectrometry

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A fragmentation study of two compounds related to 4'-demethylepipodophyllotoxin in negative ion electrospray ionization by MSn ion-trap time-of-flight mass spectrometry

21 January 2018

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Investigation on fragmentation pathways of rutaecarpine and its two derivatives using electrospray ionization ion‐trap time‐of‐flight tandem mass spectrometry

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Electrospray ionization ion-trap time-of-flight tandem mass spectrometry of two furofurans: sesamin and gmelinol

21 January 2018

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Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy

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Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI- IT-TOF/MS: Shengmai injection as

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Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS.

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Profiling and biomarker identification in plasma from different Zucker rat strains via high mass accuracy multistage mass spectrometric analysis using liquid chromatography/mass spectrometry with a quadrupole ion trap-time of flight mass spectromete

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Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

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Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

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An integrated method for degradation products detection and characterization using hybrid ion trap/time-of-flight mass spectrometry and data processing techniques: Application to study of the degradation products of danofloxacin under stressed condi

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Analysis of the modification site in a small molecule-modified peptide by ion trap/time-of-flight hybrid mass spectrometry

21 January 2018

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'Information-Based-Acquisition' (IBA) technique with an ion-trap/time-of-flight mass spectrometer for high-throughput and reliable protein profiling.

21 January 2018

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Application of electrospray ionization ion trap/time-of-flight mass spectrometry for chemically-synthesized small RNAs

21 January 2018

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Theoretical calculations for mass resolution of a quadrupole ion trap reflectron time-of-flight mass spectrometer.

21 January 2018

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HPLC-high resolution mass spectrometry in clinical laboratory?

21 January 2018

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Using high-resolution quadrupole TOF technology in DMPK analyses

21 January 2018

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Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS.

21 January 2018

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Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry

21 January 2018

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The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken

21 January 2018

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The metabolism of olaquindox in rats, chickens and pigs

21 January 2018

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Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s

21 January 2018

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Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry

21 January 2018

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An approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatography-ion trap-time of flight mass spectrometry analysis.

21 January 2018

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Application of a hybrid ion trap/time-of-flight mass spectrometer in metabolite characterization studies: structural identification of the metabolism profile of antofloxacin in rats rapidly using MSn information and accurate mass measurements.

21 January 2018

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Application of electrospray ionization hybrid ion trap/time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro

21 January 2018

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Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: gender-related difference in metabolism of Schisandra lignans in rats.

21 January 2018

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Metabolism of mequindox in liver microsomes of rats, chicken and pigs

21 January 2018

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Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox.

21 January 2018

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Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry.

21 January 2018

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Analytical strategies for identifying drug metabolites

21 January 2018

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Current and future trends in the application of HPLC-MS to metabolite-identification studies

21 January 2018

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Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadruple time-of-flight mass spectrometry and in-silico prediction

21 January 2018

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Drug metabolite profiling and identification by high-resolution mass spectrometry.

21 January 2018

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Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

21 January 2018

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Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JMS.3126

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28 August 2017

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