(Q38074989)

28 August 2017

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title

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development (English)

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28 August 2017

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Michael W Sinz

1

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28 August 2017

language of work or name

English

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publication date

1 February 2013

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28 August 2017

published in

Drug Metabolism Reviews

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28 August 2017

volume

45

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28 August 2017

issue

1

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28 August 2017

page(s)

3-14

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Understanding nuclear receptors using computational methods

28 August 2017

cites work

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21 January 2018

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Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

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21 January 2018

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Evaluation of models for predicting drug-drug interactions due to induction

21 January 2018

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Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model

21 January 2018

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Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach

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Cytochrome P450 and xenobiotic receptor humanized mice

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Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction

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Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase

21 January 2018

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Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination

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Machine learning methods and docking for predicting human pregnane X receptor activation

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21 January 2018

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Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: extrapolation to human CYP3A4 induction potential

21 January 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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21 January 2018

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An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism

21 January 2018

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Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules.

21 January 2018

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Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells

21 January 2018

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21 January 2018

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In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies

21 January 2018

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21 January 2018

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Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

21 January 2018

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Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

21 January 2018

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21 January 2018

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2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues

21 January 2018

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Implications and consequences of enzyme induction on preclinical and clinical drug development

21 January 2018

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Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays

21 January 2018

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Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay

21 January 2018

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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

21 January 2018

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10.3109/03602532.2012.743560

21 January 2018

Identifiers

DOI

1 reference

release_du4q2cr3e5f2zihx2kahswksj4

28 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/du4q2cr3e5f2zihx2kahswksj4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference