(Q38083655)

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Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature

scientific article published on 28 January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature (English)

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

4

object named as

Marc Ladanyi

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

author name string

Alison O'Neill

1

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Nilay Shah

2

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Naamah Zitomersky

3

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Neerav Shukla

5

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Aykut Uren

6

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

David Loeb

7

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

Jeffrey Toretsky

8

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Europe PubMed Central

PMC publication ID

28 August 2017

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28 January 2013

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Europe PubMed Central

PMC publication ID

28 August 2017

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

2013

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Europe PubMed Central

PMC publication ID

28 August 2017

450478

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

1 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors

1 reference

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6 September 2017

Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group

1 reference

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6 September 2017

Targeting of insulin-like growth factor type 1 receptor in Ewing sarcoma: unfulfilled promise or a promising beginning?

1 reference

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6 September 2017

Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma

1 reference

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6 September 2017

R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study

1 reference

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6 September 2017

Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody

1 reference

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6 September 2017

Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.

1 reference

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6 September 2017

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group

1 reference

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6 September 2017

High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition

1 reference

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6 September 2017

Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program.

1 reference

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6 September 2017

Detection and characterization of side population in Ewing's sarcoma SK-ES-1 cells in vitro

1 reference

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6 September 2017

The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma

1 reference

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6 September 2017

Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

1 reference

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6 September 2017

Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer

1 reference

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6 September 2017

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

6 September 2017

Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.

1 reference

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6 September 2017

An overview of HER2.

1 reference

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6 September 2017

Mechanisms of transformation by the BCR/ABL oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

6 September 2017

Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

6 September 2017

Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

6 September 2017

Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

14 September 2017

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

14 September 2017

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569907

14 September 2017

Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

1 reference

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14 September 2017

Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor.

1 reference

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Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma

1 reference

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14 September 2017

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

1 reference

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Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

1 reference

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Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

1 reference

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28 September 2017

The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

1 reference

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28 September 2017

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

1 reference

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23 June 2018

Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals

1 reference

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23 June 2018

Insulin-like growth factor-I-dependent growth and in vitro chemosensitivity of Ewing's sarcoma and peripheral primitive neuroectodermal tumour cell lines

1 reference

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The monoclonal HBA-71 antibody modulates proliferation of thymocytes and Ewing's sarcoma cells by interfering with the action of insulin-like growth factor I

1 reference

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23 June 2018

Type I and type II insulin-like growth factor receptors and their function in human Ewing's sarcoma cells

1 reference

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23 June 2018

Expression of insulin-like growth factor system components in Ewing's sarcoma and their association with survival.

1 reference

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31 August 2018

The pediatric preclinical testing program: description of models and early testing results.

1 reference

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31 August 2018

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

1 reference

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31 August 2018

Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells

1 reference

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31 August 2018

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

1 reference

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31 August 2018

Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice

1 reference

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1 October 2018

A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23431249

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor type 1 (IGF-1) and IGF binding protein-3 in patients with Ewing sarcoma family of tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23431249

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/23431249

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based on heuristic

inferred from PubMed ID database lookup

Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/23431249

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2013/450478

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 August 2017

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