(Q38084696)

28 August 2017

title

Protein-fatty acid complexes: biochemistry, biophysics and function (English)

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28 August 2017

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3

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28 August 2017

Steffen Thiel

2

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author name string

Christel R Brinkmann

series ordinal

1

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28 August 2017

language of work or name

English

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publication date

18 March 2013

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28 August 2017

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28 August 2017

volume

280

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28 August 2017

issue

8

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28 August 2017

page(s)

1733-1749

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Apoptosis induced by a human milk protein

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Conversion of alpha-lactalbumin to a protein inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

A folding variant of alpha-lactalbumin with bactericidal activity against Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Protein oligomerization induced by oleic acid at the solid-liquid interface--equine lysozyme cytotoxic complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The toxicity of bovine α-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

alpha-Lactalbumin: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Evidence for identity between the equilibrium unfolding intermediate and a transient folding intermediate: a comparative study of the folding reactions of alpha-lactalbumin and lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Conformation-dependent interaction of alpha-lactalbumin with model and biological membranes: a spin-label ESR study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Interaction of alpha-lactalbumin with dimyristoyl phosphatidylcholine vesicles. I. A microcalorimetric and fluorescence study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Fast mapping of global protein folding states by multivariate NMR: a GPS for proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

α-Lactalbumin forms with oleic acid a high molecular weight complex displaying cytotoxic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: a study using charge-specific chemical modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Preparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human α-lactalbumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Applications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

A novel method for preparation of HAMLET-like protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Can misfolded proteins be beneficial? The HAMLET case

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET forms annular oligomers when deposited with phospholipid monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Oxidative regulation of fatty acid-induced tau polymerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The role of decorated SDS micelles in sub-CMC protein denaturation and association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

SDS-induced fibrillation of alpha-synuclein: an alternative fibrillation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Protein misfolding, evolution and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Oleic acid is a key cytotoxic component of HAMLET-like complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET interacts with histones and chromatin in tumor cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Breakthrough in the treatment of warts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET treatment delays bladder cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Alternatively folded proteins with unexpected beneficial functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Changes in proteasome structure and function caused by HAMLET in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Lipoprotein Complex of Equine Lysozyme with Oleic Acid (ELOA) Interactions with the Plasma Membrane of Live Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET binding to α-actinin facilitates tumor cell detachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

BAMLET activates a lysosomal cell death program in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Membrane-bound states of alpha-lactalbumin: implications for the protein stability and conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Alpha-lactalbumin binding to membranes: evidence for a partially buried protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

HAMLET interacts with lipid membranes and perturbs their structure and integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Interaction of antitumor alpha-lactalbumin-oleic acid complexes with artificial and natural membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Comparison of the activity of human and bovine milk on two cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Antiproliferative effects of yogurt fractions obtained by membrane dialysis on cultured mammalian intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Induction of cell death in RAW 264.7 cells by alpha-lactalbumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

IEC-6 intestinal cell death induced by bovine milk alpha-lactalbumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Involvement of SDS-stable higher M(r) forms of bovine normal milk alpha-lactalbumin in inducing intestinal IEC-6 cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Pro-inflammatory effects of commercial alpha-lactalbumin on RAW 264.7 macrophages is due to endotoxin contamination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Sir David Cuthbertson Medal Lecture. Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Oleic acid causes apoptosis and dephosphorylates Bad

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Comparative toxicity of fatty acids on a macrophage cell line (J774).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Short-term and long-term effects of fatty acids in rat hepatoma AS-30D cells: the way to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Multiplication and death-type of leukemia cell lines exposed to very long-chain polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Comparative toxicity of oleic and linoleic acid on human lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Comparative toxicity of oleic acid and linoleic acid on Jurkat cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Toxicity of fatty acids on murine and human melanoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Effects of fatty acids on mitochondria: implications for cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

L-Carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Membrane partition of fatty acids and inhibition of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

alpha-Actinin interacts specifically with model membranes containing glycerides and fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Preliminary report: inhibition of cellular proteasome activity by free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

α-Lactalbumin is unfolded by all classes of surfactants but by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Compact oleic acid in HAMLET

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

Effect of protein–surfactant interactions on aggregation of β-lactoglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12204

21 January 2018

Identifiers

DOI

10.1111/FEBS.12204

1 reference

28 August 2017

1 reference