(Q38088287)

28 August 2017

title

Developing assays for kinase drug discovery - where have the advances come from? (English)

1 reference

28 August 2017

1 reference

Kurt W Vogel

1

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28 August 2017

Zhong Zhong

series ordinal

2

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28 August 2017

Kun Bi

series ordinal

3

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28 August 2017

Brian A Pollok

series ordinal

4

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28 August 2017

language of work or name

English

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publication date

1 January 2008

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

3

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28 August 2017

issue

1

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28 August 2017

page(s)

115-129

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High-throughput screening assays for the identification of chemical probes

28 August 2017

cites work

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21 January 2018

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

21 January 2018

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Active and inactive protein kinases: structural basis for regulation

21 January 2018

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The conformational plasticity of protein kinases

21 January 2018

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Regulation of protein kinases; controlling activity through activation segment conformation

21 January 2018

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Structural basis for control by phosphorylation

21 January 2018

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Kinetic and catalytic mechanisms of protein kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

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Rational design of inhibitors that bind to inactive kinase conformations

21 January 2018

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A general strategy for creating "inactive-conformation" abl inhibitors

21 January 2018

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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

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A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases

21 January 2018

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Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38alpha protein kinase

21 January 2018

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Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors

21 January 2018

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Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery

21 January 2018

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A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures

21 January 2018

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Label-free detection of small-molecule-protein interactions by using nanowire nanosensors

21 January 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

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A High-Throughput, Nonisotopic, Competitive Binding Assay for Kinases Using Nonselective Inhibitor Probes (ED-NSIP™)

21 January 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

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Development and validation of a fluorescence technology for both primary and secondary screening of kinases that facilitates compound selectivity and site-specific inhibitor determination

21 January 2018

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Applications of fluorescent polymer superquenching to high throughput screening assays for protein kinases

21 January 2018

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High-throughput screening with immobilized metal ion affinity-based fluorescence polarization detection, a homogeneous assay for protein kinases

21 January 2018

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Protein kinase recognition sequence motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

10 Design and use of peptide substrates for protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Docking interactions in the c-Jun N-terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Comparative analysis of various in vitro COT kinase assay formats and their applications in inhibitor identification and characterization

21 January 2018

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GPCR screening via ERK 1/2: a novel platform for screening G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Time-resolved fluorescence resonance energy transfer kinase assays using physiological protein substrates: applications of terbium-fluorescein and terbium-green fluorescent protein fluorescence resonance energy transfer pairs.

21 January 2018

1 reference

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A substrate for deubiquitinating enzymes based on time-resolved fluorescence resonance energy transfer between terbium and yellow fluorescent protein.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A generic, homogenous method for measuring kinase and inhibitor activity via adenosine 5'-diphosphate accumulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Versatile fluorescence probes of protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Cellular platforms for HTS: three case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A fluorescent reporter assay for the detection of ligands acting through Gi protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Preparation and characterization of calibration beads for sorting cells expressing a beta-lactamase gene reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Lentiviruses as gene transfer agents for delivery to non-dividing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Generation of Stably Transfected Mammalian Cell Lines as Fluorescent Screening Assay for NF-κB Activation-Dependent Gene Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A gain-of-function mutation of JAK2 in myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A novel genetic system to detect protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Detection of TAP family dimerizations by an in vivo assay in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

A homogeneous cell-based assay to measure nuclear translocation using beta-galactosidase enzyme fragment complementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Identifying off-target effects and hidden phenotypes of drugs in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

An efficient rapid system for profiling the cellular activities of molecular libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

Ba/F3 cells and their use in kinase drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.1.115

21 January 2018

Identifiers

DOI

10.1517/17460441.3.1.115

1 reference

28 August 2017

1 reference