(Q38096239)

English

The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity.

scientific article published on 04 April 2013

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28 February 2020

The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity (English)

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28 February 2020

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28 February 2020

Hans-Joachim Gabius

3

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28 February 2020

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Paul V Murphy

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28 February 2020

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28 February 2020

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28 February 2020

4026-4053

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28 February 2020

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Creative Commons Attribution 4.0 International

4 April 2013

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April 2022 Public Data File from Crossref

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0 references

Post-translation modification of proteins; methodologies and applications in plant sciences

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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1 reference

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21 January 2018

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21 January 2018

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1 reference

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21 January 2018

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1 reference

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21 January 2018

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1 reference

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21 January 2018

Carbohydrate analysis throughout the development of a protein therapeutic

1 reference

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21 January 2018

Exploring genomes for glycosyltransferases.

1 reference

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21 January 2018

The sugar code: functional lectinomics

1 reference

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21 January 2018

The repertoire of glycan determinants in the human glycome

1 reference

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21 January 2018

Fucosylation in prokaryotes and eukaryotes

1 reference

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21 January 2018

Fucose, placental evolution and the glycocode

1 reference

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21 January 2018

The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.

1 reference

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21 January 2018

Characterization of mouse sialyltransferase genes: their evolution and diversity

1 reference

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21 January 2018

Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.

1 reference

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21 January 2018

Developmental diseases caused by impaired nucleotide sugar transporters

1 reference

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21 January 2018

Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional alpha 2,3/alpha 2,6 sialylation: synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptake

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Carbohydrate-binding proteins: tertiary structures and protein-sugar interactions

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

From lectin structure to functional glycomics: principles of the sugar code.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Selectins and glycosyltransferases in leukocyte rolling in vivo

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Hepatic uptake of proteins coupled to fetuin glycopeptide

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

New synthetic cluster ligands for galactose/N-acetylgalactosamine-specific lectin of mammalian liver

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Involvement of laser photo-CIDNP (chemically induced dynamic nuclear polarization)-reactive amino acid side chains in ligand binding by galactoside-specific lectins in solution.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: different structural alterations upon oxidation and ligand binding.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectins: a family of animal lectins that decipher glycocodes

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectinomics: finding themes in complexity

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Comparative cross-linking activities of lactose-specific plant and animal lectins and a natural lactose-binding immunoglobulin G fraction from human serum with asialofetuin

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Purification and characterization of beta-galactoside-binding lectin from chick embryonic skin.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Neoglycoconjugates based on cyclodextrins and calixarenes.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Carbamate-linked lactose: design of clusters and evidence for selectivity to block binding of human lectins to (neo)glycoproteins with increasing degree of branching and to tumor cells

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

A self-assembled multivalent pseudopolyrotaxane for binding galectin-1.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Ganglioside GM1/galectin-dependent growth regulation in human neuroblastoma cells: special properties of bivalent galectin-4 and significance of linker length for ligand selection.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactose/lactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesion/growth-regula

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Strained cyclophane natural products: macrocyclization at its limits

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: stereoselective synthesis of glycosides and 2-deoxyglycosides

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

The development of L2X2Ru=CHR olefin metathesis catalysts: an organometallic success story

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Human splenic galaptin: carbohydrate-binding specificity and characterization of the combining site

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Inhibitory potential of chemical substitutions at bioinspired sites of β-D-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Oligosaccharide specificity of galectins: a search by frontal affinity chromatography.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

N-domain of human adhesion/growth-regulatory galectin-9: preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Structural aspects of binding of α-linked digalactosides to human galectin-1

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Lactose-containing starburst dendrimers: influence of dendrimer generation and binding-site orientation of receptors (plant/animal lectins and immunoglobulins) on binding properties

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Correlation of expression of binding sites for synthetic blood group A-, B- and H-trisaccharides and for sarcolectin with survival of patients with bronchial carcinoma.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Effects of polyvalency of glycotopes and natural modifications of human blood group ABH/Lewis sugars at the Galβ1-terminated core saccharides on the binding of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Recent Advances on Cyclopeptide-Based Glycoclusters

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES18044026

21 January 2018

The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of endogenous lectins in normal human breast, benign breast lesions and mammary carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological information transfer beyond the genetic code: the sugar code

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding characteristics of galactoside-binding lectin (galaptin) from human spleen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of β1,4-galactosyltransferases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and properties of beta-D-galactoside-specific lectin from chick embryo thigh muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two lactose binding lectins from chicken tissues. Purified lectin from intestine is different from those in liver and muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of Ugi reactions in synthesis of divalent neoglycoconjugates: evidence that the sugars are presented in restricted conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitutions in theN-Glycan Core as Regulators of Biorecognition: The Case of Core-Fucose and Bisecting GlcNAc Moieties†

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combinatorial Solid-Phase Synthesis of Multivalent Cyclic Neoglycopeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse lectin histochemistry: design and application of glycoligands for detection of cell and tissue lectins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous sugar receptor (lectin) profiles of human retinoblastoma and retinoblast cell lines analyzed by cytological markers, affinity chromatography and neoglycoprotein-targeted photolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined analysis of tumor growth pattern and expression of endogenous lectins as a prognostic tool in primary testicular cancer and its lung metastases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple soluble beta-galactoside-binding lectins from human lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous sugar-binding proteins in human breast tissue and benign and malignant breast lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different architecture of the combining site of the two chicken galectins revealed by chemical mapping studies with synthetic ligand derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23558543

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES18044026

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558543%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558543%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558543%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

ResearchGate publication ID

0 references

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