(Q38097498)

28 August 2017

title

Pathogen recognition receptors: ligands and signaling pathways by Toll-like receptors (English)

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28 August 2017

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Miwa Sasai

1

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28 August 2017

Masahiro Yamamoto

series ordinal

2

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28 August 2017

publication date

1 April 2013

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International Reviews of Immunology

28 August 2017

published in

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28 August 2017

volume

32

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28 August 2017

issue

2

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28 August 2017

page(s)

116-133

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Toll-like receptors: critical proteins linking innate and acquired immunity

28 August 2017

cites work

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Innate immune recognition

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

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Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

21 January 2018

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Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Structures of the toll-like receptor family and its ligand complexes

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

CD36 is a sensor of diacylglycerides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A toll-like receptor that prevents infection by uropathogenic bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A mouse model of Salmonella typhi infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Murine retroviruses activate B cells via interaction with toll-like receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Toll-like receptor and RIG-I-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TLR3 deficiency in patients with herpes simplex encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Immune signaling by RIG-I-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The dsRNA binding site of human Toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Innate immune recognition of viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Autophagy-dependent viral recognition by plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Granulin is a soluble cofactor for toll-like receptor 9 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Herpes simplex virus encephalitis in human UNC-93B deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Intracellular toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Cathepsins are required for Toll-like receptor 9 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TIR-containing adaptors in Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

MyD88, an adapter protein involved in interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Ubiquitylation in innate and adaptive immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Innate immune functions of plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The IRF family transcription factors in immunity and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Negative regulation of Toll-like-receptor signaling by IRF-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Negative regulation of signaling by a soluble form of toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

IRAK-M is a negative regulator of Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

SMAD4 is required for development of maximal endotoxin tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2013.774391

10.3109/08830185.2013.774391

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference