(Q38097859)

28 August 2017

title

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease (English)

1 reference

28 August 2017

0 references

5

Hilkka Soininen

0 references

Annakaisa Haapasalo

2

object named as

Annakaisa Haapasalo

0 references

Jussi Pihlajamäki

4

object named as

Jussi Pihlajamäki

0 references

author name string

Henna Martiskainen

1

1 reference

28 August 2017

Kaisa M A Kurkinen

3

1 reference

28 August 2017

Mikko Hiltunen

6

1 reference

28 August 2017

language of work or name

English

0 references

publication date

11 April 2013

1 reference

Expert Opinion on Therapeutic Targets

28 August 2017

published in

1 reference

28 August 2017

volume

17

1 reference

28 August 2017

issue

7

1 reference

28 August 2017

page(s)

781-794

1 reference

Epidemiology of Alzheimer disease

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The genetic epidemiology of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Assembly of the presenilin γ-/ε-secretase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Protection against Alzheimer's disease with apoE epsilon 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Reelin, lipoprotein receptors and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP: a multifunctional scavenger and signaling receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Signaling through LRP1: Protection from atherosclerosis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

All Three LDL Receptor Homology Regions of the LDL Receptor-Related Protein Bind Multiple Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Clearance of amyloid beta-peptide from brain: transport or metabolism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The blood-brain barrier in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Brain insulin impairs amyloid-beta(1-40) clearance from the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

LRP1 shedding in human brain: roles of ADAM10 and ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Decreased plasma levels of soluble low density lipoprotein receptor-related protein-1 (sLRP) and the soluble form of the receptor for advanced glycation end products (sRAGE) in the clinical diagnosis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Clearance of amyloid-beta by circulating lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Protein metabolism and liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Plasma beta-amyloid (A beta) 40 concentration, lipid status and age in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The Alzheimer's disease beta-secretase enzyme, BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Phosphorylation of LRP1 regulates the interaction with Fe65

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Up-regulation of hepatic low-density lipoprotein receptor-related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl-coenzyme A reductase inhibitor Atorvastatin and hepatic LRP1 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.789862

10.1517/14728222.2013.789862

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference