(Q38100970)

28 August 2017

Blood-brain barrier structure and function and the challenges for CNS drug delivery (English)

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28 August 2017

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N Joan Abbott

1

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28 August 2017

23 April 2013

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Journal of Inherited Metabolic Disease

28 August 2017

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28 August 2017

36

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28 August 2017

3

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28 August 2017

437-449

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https://scigraph.springernature.com/pub.10.1007/s10545-013-9608-0

28 August 2017

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21 January 2018

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Assays to predict drug permeation across the blood-brain barrier, and distribution to brain.

21 January 2018

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Structure and function of the blood-brain barrier

21 January 2018

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Therapies for neurological disease in the mucopolysaccharidoses.

21 January 2018

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Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment

21 January 2018

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Pericytes regulate the blood-brain barrier

21 January 2018

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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?

21 January 2018

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Lysosomal storage diseases and the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging

21 January 2018

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Pathophysiology of neuropathic lysosomal storage disorders

21 January 2018

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Circumventricular organs: receptive and homeostatic functions and clinical implications

21 January 2018

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Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Systemic delivery of a glucosylceramide synthase inhibitor reduces CNS substrates and increases lifespan in a mouse model of type 2 Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Will the original glucose transporter isoform please stand up!

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

In vitro model for evaluating drug transport across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Modelling of the blood-brain barrier in drug discovery and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Pericytes are required for blood-brain barrier integrity during embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Intrathecal enzyme replacement therapy for mucopolysaccharidosis I: translating success in animal models to patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Capture, crawl, cross: the T cell code to breach the blood-brain barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Correction of neurological disease of mucopolysaccharidosis IIIB in adult mice by rAAV9 trans-blood-brain barrier gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-brain barrier impairment in an animal model of MPS III B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

New strategies for enzyme replacement therapy for lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Evaluation of miglustat treatment in patients with type III mucopolysaccharidosis: a randomized, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

On the rate and extent of drug delivery to the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Intercellular interactomics of human brain endothelial cells and th17 lymphocytes: a novel strategy for identifying therapeutic targets of CNS inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Lessons learnt from animal models: pathophysiology of neuropathic lysosomal storage disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

CNS delivery via adsorptive transcytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Glial regulation of the cerebral microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Human ABC transporter ABCG2 in cancer chemotherapy: drug molecular design to circumvent multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-brain barrier transport of therapeutics via receptor-mediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Synthetic genistein derivatives as modulators of glycosaminoglycan storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Slice cultures as a model to study neurovascular coupling and blood brain barrier in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Anti-Aβ-MAb and dually decorated nanoliposomes: effect of Aβ1-42 peptides on interaction with hCMEC/D3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Transport of arylsulfatase A across the blood-brain barrier in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Enzyme replacement improves ataxic gait and central nervous system histopathology in a mouse model of metachromatic leukodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Pathways of clathrin-independent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Immunologic privilege in the central nervous system and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

In vitro blood-brain barrier models: current and perspective technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Mechanisms of disease: the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Engaging neuroscience to advance translational research in brain barrier biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

In vitro modeling of the blood-brain barrier: simplicity versus complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Medicinal chemical properties of successful central nervous system drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Substrate reduction therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

The anatomical and cellular basis of immune surveillance in the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Trans-generational exposure to low levels of rhodamine B does not adversely affect litter size or liver function in murine mucopolysaccharidosis type IIIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Barrier mechanisms in the developing brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Therapeutic approaches for neuronopathic lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Clarifying lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Endothelial transcytosis in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Transport of interleukin-1 across cerebromicrovascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Targeted delivery of proteins across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Pathophysiology of the neurovascular unit: disease cause or consequence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Delivery of drugs to the brain via the blood brain barrier using colloidal carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

The role of inflammation in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Common and uncommon pathogenic cascades in lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Central nervous system pericytes in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Tanycytes and pituicytes: morphological and functional aspects of neuroglial interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood–brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-013-9608-0

Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance

21 January 2018

1 reference

12 December 2020

Neurodegeneration and the neurovascular unit

1 reference

12 December 2020

Absence of albumin receptor on brain capillaries in vivo or in vitro

1 reference

12 December 2020

Structural and functional aspects of the blood-brain barrier.

1 reference

12 December 2020

In vitro models of the blood-brain barrier

1 reference

12 December 2020

A combined artificial chromosome-stem cell therapy method in a model experiment aimed at the treatment of Krabbe’s disease in the Twitcher mouse

1 reference

12 December 2020

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy

1 reference

12 December 2020

Overview and introduction: the blood-brain barrier in health and disease

1 reference

12 December 2020

In vitro models of the blood-brain barrier

1 reference

12 December 2020

Human ABC transporters ABCG2 (BCRP) and ABCG4

1 reference

12 December 2020

Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease

1 reference

12 December 2020

The impact of pericytes on the blood-brain barrier integrity depends critically on the pericyte differentiation stage

1 reference

12 December 2020

Insulin-like growth factors cross the blood-brain barrier

1 reference

12 December 2020

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

12 December 2020

Apical-to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein

1 reference

12 December 2020

Prediction of blood-brain barrier penetration: are we missing the point?

1 reference

12 December 2020

Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier

1 reference

12 December 2020

The flexibility of P-glycoprotein for its poly-specific drug binding from molecular dynamics simulations

1 reference

12 December 2020

A review of blood-brain barrier transport techniques

1 reference

12 December 2020

An overview of in vitro techniques for blood-brain barrier studies

1 reference

12 December 2020

Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models

1 reference

12 December 2020

Intracisternal enzyme replacement therapy in lysosomal storage diseases: routes of absorption into brain

1 reference

12 December 2020

Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging

1 reference

12 December 2020

Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.

1 reference

12 December 2020

New strategies for the treatment of lysosomal storage diseases (review).

1 reference

12 December 2020

10.1007/S10545-013-9608-0

Identifiers

DOI

1 reference

PubMed ID

23609350

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23609350