(Q38103907)

28 August 2017

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives (English)

1 reference

28 August 2017

0 references

3

Ae Nim Pae

1 reference

28 August 2017

TaeHun Kim

1

1 reference

PubMed ID

23641970

28 August 2017

Gyochang Keum

series ordinal

2

1 reference

PubMed ID

23641970

28 August 2017

language of work or name

English

0 references

publication date

4 May 2013

1 reference

Expert Opinion on Therapeutic Patents

28 August 2017

1 reference

28 August 2017

23

1 reference

28 August 2017

8

1 reference

28 August 2017

919-943

1 reference

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Discovery and development of heat shock protein 90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Geldanamycin and its anti-cancer activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Geldanamycin and its derivatives as Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Targeting the dynamic HSP90 complex in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Herbimycin, a new antibiotic produced by a strain of Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Update on Hsp90 inhibitors in clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Structure-based design of 7-carbamate analogs of geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780597

Reblastatin, a novel benzenoid ansamycin-type cell cycle inhibitor

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.1310

Macbecins I and II, new antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.33.199

Identifiers

DOI

10.1517/13543776.2013.780597

1 reference

28 August 2017

1 reference

PubMed ID

23641970