(Q38107250)

29 August 2017

Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications (English)

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29 August 2017

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J Bhat

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Ottmar Janssen

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O Janssen

4

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author name string

G Chitadze

1

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PubMed ID

23679194

29 August 2017

M Lettau

3

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PubMed ID

23679194

29 August 2017

D Kabelitz

5

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29 August 2017

1 August 2013

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Scandinavian Journal of Immunology

29 August 2017

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29 August 2017

78

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29 August 2017

120-129

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29 August 2017

2

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Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

29 August 2017

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Natural cytotoxicity receptors: broader expression patterns and functions in innate and adaptive immune cells.

21 January 2018

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NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence

21 January 2018

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Vis-à-vis in the NKC: genetically linked natural killer cell receptor/ligand pairs in the natural killer gene complex (NKC).

21 January 2018

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Regulation of immune cell function and differentiation by the NKG2D receptor

21 January 2018

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Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion

21 January 2018

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Line of attack: NK cell specificity and integration of signals

21 January 2018

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Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors.

21 January 2018

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Innate or adaptive immunity? The example of natural killer cells

21 January 2018

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Roles of the NKG2D immunoreceptor and its ligands

21 January 2018

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Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

21 January 2018

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An activating immunoreceptor complex formed by NKG2D and DAP10

21 January 2018

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NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

21 January 2018

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NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

21 January 2018

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Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.

21 January 2018

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NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease

21 January 2018

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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

21 January 2018

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MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function

21 January 2018

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NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d

21 January 2018

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Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells

21 January 2018

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Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.

21 January 2018

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NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

21 January 2018

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Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor

21 January 2018

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Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

21 January 2018

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Human NKG2D-ligands: cell biology strategies to ensure immune recognition

21 January 2018

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Regulation of ligands for the NKG2D activating receptor

21 January 2018

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The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells.

21 January 2018

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Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells

21 January 2018

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Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA.

21 January 2018

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Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells.

21 January 2018

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Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.

21 January 2018

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Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate

21 January 2018

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Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity

21 January 2018

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Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma

21 January 2018

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Regulation of NKG2D-ligand cell surface expression by intracellular calcium after HDAC-inhibitor treatment

21 January 2018

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Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis

21 January 2018

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Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine

21 January 2018

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IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells.

21 January 2018

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HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines

21 January 2018

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Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells.

21 January 2018

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MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells

21 January 2018

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Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor

21 January 2018

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Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.

21 January 2018

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Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gamma-induced microRNA

21 January 2018

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TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

21 January 2018

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Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein

21 January 2018

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NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142.

21 January 2018

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Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus.

21 January 2018

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Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression

21 January 2018

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CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells

21 January 2018

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Brief residence at the plasma membrane of the MHC class I-related chain B is due to clathrin-mediated cholesterol-dependent endocytosis and shedding

21 January 2018

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Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.

21 January 2018

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Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.

21 January 2018

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NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting

21 January 2018

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Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses.

21 January 2018

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Activation of V gamma 9V delta 2 T cells by NKG2D.

21 January 2018

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Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

21 January 2018

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Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients

21 January 2018

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Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein

21 January 2018

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Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression

21 January 2018

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Proteolytic release of soluble UL16-binding protein 2 from tumor cells

21 January 2018

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Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands

21 January 2018

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RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity

21 January 2018

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Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

21 January 2018

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Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells

21 January 2018

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MMP9 mediates MICA shedding in human osteosarcomas

21 January 2018

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The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases

21 January 2018

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The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

21 January 2018

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ADAMs: key components in EGFR signalling and development

21 January 2018

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Control of death receptor ligand activity by posttranslational modifications.

21 January 2018

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The ADAMs: signalling scissors in the tumour microenvironment

21 January 2018

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Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

21 January 2018

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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

21 January 2018

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

21 January 2018

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Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9.

21 January 2018

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Tumor-associated MICA is shed by ADAM proteases

21 January 2018

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Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.

21 January 2018

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Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding

21 January 2018

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Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

21 January 2018

1 reference

ADAM-17: the enzyme that does it all.

21 January 2018

1 reference

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes

21 January 2018

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Human tumor-derived exosomes down-modulate NKG2D expression.

21 January 2018

1 reference

Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha

21 January 2018

1 reference

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

21 January 2018

1 reference

Modulation of NKG2D-ligand cell surface expression enhances immune cell therapy of cancer

21 January 2018

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Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

21 January 2018

1 reference

Soluble NKG2D ligands: prevalence, release, and functional impact.

21 January 2018

1 reference

Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection

21 January 2018

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Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma

21 January 2018

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Diagnostic and prognostic impact of serum-soluble UL16-binding protein 2 in lung cancer patients.

21 January 2018

1 reference

Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.

21 January 2018

1 reference

Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G.

21 January 2018

1 reference

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/SJI.12072

1 reference

29 August 2017

1 reference

PubMed ID

23679194