(Q38109231)

29 August 2017

Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing (English)

1 reference

29 August 2017

Mario Pellegatti

1

1 reference

PubMed ID

23705836

29 August 2017

language of work or name

English

0 references

publication date

25 May 2013

1 reference

Expert Opinion on Drug Metabolism & Toxicology

29 August 2017

1 reference

29 August 2017

9

1 reference

29 August 2017

1171-1180

1 reference

29 August 2017

9

1 reference

Are animal models predictive for humans?

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The ethics of animal research. Talking Point on the use of animals in scientific research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Ethical and scientific considerations regarding animal testing and research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Medical progress depends on animal models - doesn't it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Systematic reviews of animal models: methodology versus epistemology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Toxicology for the twenty-first century

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Inroads to predict in vivo toxicology-an introduction to the eTOX Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Toxicity testing in the 21st century: bringing the vision to life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Toxicology in the 21st century--working our way towards a visionary reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

From alternative methods to a new toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

A 1-year toxicity study in dogs is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

ICH guidelines: inception, revision, and implications for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Preclinical in vivo ADME studies in drug development: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Critical evaluation of the use of dogs in biomedical research and testing in Europe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The RETHINK project--minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Animal models of toxicology testing: the role of pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Safety evaluation of biological drugs: what are toxicology studies in primates telling us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Considerations regarding nonhuman primate use in safety assessment of biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Present state and future perspectives of using pluripotent stem cells in toxicology research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Application of advanced in silico methods for predictive modeling and information integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Human clearance prediction: shifting the paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Preclinical safety evaluation using nonrodent species: an industry/welfare project to minimize dog use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

The end of monkey research? New legislation and public pressure could jeopardize research with primates in both Europe and the USA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Understanding pharmacology in humans: Phase I and Phase II (data generation).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Investigative safety science as a competitive advantage for Pharma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.804061

10.1517/17425255.2013.804061

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23705836