(Q37764345)

22 August 2017

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title

Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling (English)

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22 August 2017

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Jong Hwan Sung

1

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22 August 2017

Mandy B Esch

series ordinal

2

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22 August 2017

Michael L Shuler

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Opinion on Drug Metabolism & Toxicology

22 August 2017

published in

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22 August 2017

volume

6

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22 August 2017

issue

9

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22 August 2017

page(s)

1063-1081

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Recent advances in high throughput screening for ADME properties

22 August 2017

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Bayesian calibration of a physiologically based pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase inhibition

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An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat

21 January 2018

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A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

21 January 2018

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Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat

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A combined pharmacokinetic-pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration

21 January 2018

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Analysis of single mammalian cells on-chip

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A driving force for change: interstitial flow as a morphoregulator.

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Oxygen: modulator of physiological and pathophysiological processes in the liver

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Biomolecular gradients in cell culture systems

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Labs on a chip: meet the stripped down rat.

21 January 2018

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Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

21 January 2018

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In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates

21 January 2018

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Three-dimensional cellular microarray for high-throughput toxicology assays

21 January 2018

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Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor.

21 January 2018

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Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

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Development of a microscale cell culture analog to probe naphthalene toxicity

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Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies

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A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

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Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

21 January 2018

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A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

21 January 2018

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A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

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21 January 2018

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21 January 2018

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21 January 2018

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In vitro zonation and toxicity in a hepatocyte bioreactor

21 January 2018

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21 January 2018

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21 January 2018

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Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

21 January 2018

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

21 January 2018

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Perfused multiwell plate for 3D liver tissue engineering

21 January 2018

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Microscale culture of human liver cells for drug development.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.496251

The future of hemodialysis membranes

21 January 2018

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Hemodialyzer membranes and configurations: a historical perspective

21 January 2018

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Microfabrication of three-dimensional engineered scaffolds

21 January 2018

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Membraneless dialysis--is it possible?

21 January 2018

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Dialysis without membranes: how and why?

21 January 2018

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Continuously functioning artificial nephron system: the promise of nanotechnology

21 January 2018

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Dialysis and nanotechnology: now, 10 years, or never?

21 January 2018

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Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure

21 January 2018

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The wearable artificial kidney, why and how: from holy grail to reality

21 January 2018

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Microchannel technologies for artificial lungs: (1) theory

21 January 2018

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Microchannel technologies for artificial lungs: (2) screen-filled wide rectangular channels

21 January 2018

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Microchannel technologies for artificial lungs: (3) open rectangular channels

21 January 2018

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Towards microfabricated biohybrid artificial lung modules for chronic respiratory support

21 January 2018

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Strategies for absorption screening in drug discovery and development

21 January 2018

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Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

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Caco-2 monolayers in experimental and theoretical predictions of drug transport

21 January 2018

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Evaluation of viability of excised rat intestinal segments in the Ussing chamber: investigation of morphology, electrical parameters, and permeability characteristics

21 January 2018

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Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability

21 January 2018

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Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity

21 January 2018

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Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

21 January 2018

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Mechanisms and consequences of neutrophil interaction with the endothelium

21 January 2018

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Formation of perfused, functional microvascular tubes in vitro.

21 January 2018

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Endothelialized microvasculature based on a biodegradable elastomer.

21 January 2018

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Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element.

21 January 2018

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Scaling pharmacodynamics from in vitro and preclinical animal studies to humans

21 January 2018

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Microscale technologies for tissue engineering and biology

21 January 2018

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Microfluidics for drug discovery and development: from target selection to product lifecycle management

21 January 2018

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In vitro microscale systems for systematic drug toxicity study

21 January 2018

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A practical guide to microfluidic perfusion culture of adherent mammalian cells.

21 January 2018

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Where are the biologists?

21 January 2018

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Automated cell culture in high density tubeless microfluidic device arrays

21 January 2018

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Analysis of pressure-driven air bubble elimination in a microfluidic device

21 January 2018

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Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap

21 January 2018

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An integrated fluorescence detection system for lab-on-a-chip applications.

21 January 2018

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Real-time fluorescence detection of multiple microscale cell culture analog devices in situ

21 January 2018

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Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

21 January 2018

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A plate reader-compatible microchannel array for cell biology assays

21 January 2018

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Portable in situ fluorescence cytometry of microscale cell-based assays

21 January 2018

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Cellular impedance biosensors for drug screening and toxin detection.

21 January 2018

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Microelectronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity

21 January 2018

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Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity.

21 January 2018

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Adhesion of lymphocytes to hepatic endothelium

21 January 2018

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Formation of steady-state oxygen gradients in vitro: application to liver zonation

21 January 2018

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A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells.

21 January 2018

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Mechanosensory function of microvilli of the kidney proximal tubule

21 January 2018

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Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct

21 January 2018

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Mass transfer characteristics of artificial lungs.

21 January 2018

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Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2010.496251

A novel system to study the impact of epithelial barriers on cellular metabolism

21 January 2018

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Shear stress induced stimulation of mammalian cell metabolism

21 January 2018

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Techniques for mechanical stimulation of cells in vitro: a review

21 January 2018

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Neutrophils influence melanoma adhesion and migration under flow conditions

21 January 2018

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10.1517/17425255.2010.496251

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference