(Q36985051)

17 August 2017

1 reference

title

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations (English)

1 reference

ORCID Public Data File 2021

17 August 2017

1 reference

author name string

Pelkonen O

series ordinal

1

1 reference

PubMed ID

17968737

17 August 2017

Turpeinen M

series ordinal

2

1 reference

PubMed ID

17968737

17 August 2017

language of work or name

English

0 references

publication date

1 October 2007

1 reference

17 August 2017

1 reference

17 August 2017

37

1 reference

17 August 2017

10-11

1 reference

17 August 2017

1066-1089

1 reference

Cell lines as in vitro models for drug screening and toxicity studies

17 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The complexities of hepatic drug transport: current knowledge and emerging concepts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of pharmacokinetic properties using experimental approaches during early drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Present and future in vitro approaches for drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Application of cryopreserved precision-cut liver slices in pharmacotoxicology--principles, literature data and own investigations with special reference to CYP1A1-mRNA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Infection of a human hepatoma cell line by hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Acquisition and use of human in vitro liver preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Standard liver volume in the Caucasian population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Changes in liver volume from birth to adulthood: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

In vitro tests for predicting drug-drug interactions: the need for validated procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Nonspecific binding of drugs to human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Drug-protein binding sites. New trends in analytical and experimental methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Origin and characterization of a human bipotent liver progenitor cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Inhibition and induction of human cytochrome P450 (CYP) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Screening of drug candidates for their drug--drug interaction potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Transporters as a determinant of drug clearance and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Which in vitro screens guide the prediction of oral absorption and volume of distribution?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Validated assays for human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Implications and consequences of enzyme induction on preclinical and clinical drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Misuse of the well-stirred model of hepatic drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701620726

10.1080/00498250701620726

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17968737