(Q35057285)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

review article

1 reference

title

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

1 reference

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

author name string

Frank-Peter Theil

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Theodor W Guentert

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Patrick Poulin

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

publication date

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

number of pages

21

1 reference

inferred from page(s)

published in

Toxicology Letters

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

volume

138

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

issue

1-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

page(s)

29-49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12559691%20AND%20SRC:MED&resulttype=core&format=json

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

17 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: methods and application

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of in vivo tissue distribution from in vitro data 1. Experiments with markers of aqueous spaces

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Concentration dependency of rat blood: air partition coefficients of some volatile organic chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Commentary on "Physiologically based pharmacokinetic modeling as a tool for drug development"

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of drug distribution in distribution dialysis and in vivo from binding to tissues and blood.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Physiologically-based pharmacokinetic simulation modelling.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Relative lipid content as the sole mechanistic determinant of the adipose tissue:blood partition coefficients of highly lipophilic organic chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Biological determinants of propranolol disposition in man

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

In vitro human tissue models in risk assessment: report of a consensus-building workshop

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Development of predictive pharmacokinetic simulation models for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Comparison of models for the estimation of biological partition coefficients

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

An approach for incorporating tissue composition data into physiologically based pharmacokinetic models

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

In vitro studies of teicoplanin binding to rat tissues and erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Models of hepatic drug elimination

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of the volumes of distribution of basic drugs in humans based on data from animals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Enzyme kinetics of cytochrome P450-mediated reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Relationships in the structure-tissue distribution of basic drugs in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

A compartmental absorption and transit model for estimating oral drug absorption.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900374-0

7 January 2021