(Q38112652)

29 August 2017

title

Predicting drug-induced QT prolongation and torsades de pointes: a review of preclinical endpoint measures (English)

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29 August 2017

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Claire Townsend

1

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29 August 2017

Barry S Brown

series ordinal

2

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29 August 2017

publication date

1 June 2013

1 reference

Current protocols in pharmacology

29 August 2017

published in

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29 August 2017

volume

Chapter 10

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29 August 2017

page(s)

Unit 10.16

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Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

29 August 2017

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21 January 2018

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Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.

21 January 2018

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In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome

21 January 2018

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Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

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hERG channel trafficking: novel targets in drug-induced long QT syndrome

21 January 2018

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Molecular determinants of pentamidine-induced hERG trafficking inhibition

21 January 2018

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The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

21 January 2018

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Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition.

21 January 2018

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HTS techniques for patch clamp-based ion channel screening - advances and economy

21 January 2018

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Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

21 January 2018

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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

21 January 2018

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Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

21 January 2018

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Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

21 January 2018

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Method and theory of monophasic action potential recording

21 January 2018

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Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG.

21 January 2018

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An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

21 January 2018

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The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

21 January 2018

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Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.

21 January 2018

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Anti-anginal arylalkylamines and sodium channels: [3H]-batrachotoxinin-A 20-alpha-benzoate and [3H]-tetracaine binding

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk.

21 January 2018

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Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression

21 January 2018

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Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation

21 January 2018

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Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Using label-free screening technology to improve efficiency in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Torsades de pointes liability inter-model comparisons: the experience of the QT PRODACT initiative

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Precordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Electrophysiological characterization of cardiomyocytes derived from human induced pluripotent stem cells

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Modelling the long QT syndrome with induced pluripotent stem cells

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Automated patch clamping using the QPatch.

21 January 2018

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Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.

21 January 2018

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Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

21 January 2018

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Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

21 January 2018

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Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

QT PRODACT: evaluation of the potential of compounds to cause QT interval prolongation by action potential assays using guinea-pig papillary muscles

21 January 2018

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Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels

21 January 2018

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Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Amiodarone and torsade de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Lack of action potential-prolonging effect of terfenadine on rabbit myocardial tissue preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

QPatch: the missing link between HTS and ion channel drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

hERG potassium channels and the structural basis of drug-induced arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

21 January 2018

HERG1 channelopathies

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Clinical and genetic determinants of torsade de pointes risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de Pointes in models of acquired and congenital long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Cellular HTS assays for pharmacological characterization of Na(V)1.7 modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Preclinical assessment of drug-induced proarrhythmias: role of the arterially perfused rabbit left ventricular wedge preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis

21 January 2018

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https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

Cardiomyocyte differentiation of human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH1016S61

10.1002/0471141755.PH1016S61

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

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