(Q38113683)

English

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

scientific article published on 12 June 2013

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scholarly article

1 reference

Europe PubMed Central

29 August 2017

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid (English)

1 reference

Europe PubMed Central

29 August 2017

cerebrospinal fluid

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Henrik Zetterberg

2

object named as

Henrik Zetterberg

1 reference

Europe PubMed Central

29 August 2017

4

object named as

Kaj Blennow

1 reference

Europe PubMed Central

29 August 2017

author name string

Heiko Braak

1

1 reference

Europe PubMed Central

29 August 2017

Kelly Del Tredici

3

1 reference

Europe PubMed Central

29 August 2017

publication date

12 June 2013

1 reference

Europe PubMed Central

29 August 2017

Acta Neuropathologica

1 reference

Europe PubMed Central

29 August 2017

126

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Europe PubMed Central

29 August 2017

631-641

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Europe PubMed Central

29 August 2017

5

1 reference

Europe PubMed Central

29 August 2017

https://scigraph.springernature.com/pub.10.1007/s00401-013-1139-0

0 references

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Prodromal Alzheimer's disease: successive emergence of the clinical symptoms

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Microtubule transport in the axon

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid protein biomarkers for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

CSF markers for incipient Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Longitudinal stability of CSF biomarkers in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The neuropathology and neurobiology of traumatic brain injury

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Fluid biomarkers in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Duration of neurofibrillary changes in the hippocampal pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Alzheimer's disease: pathogenesis and prevention.

1 reference

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21 January 2018

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Advance in the pathogenesis and treatment of Wilson disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Classification and basic pathology of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Hyperphosphorylated tau in young and middle-aged subjects

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The magical number four: A biological, historical and mythological enigma

1 reference

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21 January 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

1 reference

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21 January 2018

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

1 reference

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21 January 2018

Mechanisms of tau-induced neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The amyloid cascade hypothesis.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Transition of tau protein from disordered to misordered in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Biochemistry and cell biology of tau protein in neurofibrillary degeneration

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Structural principles of tau and the paired helical filaments of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Neuropathologic substrate of mild cognitive impairment.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Pathways towards and away from Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The spectrum of disease in chronic traumatic encephalopathy

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Neurons may live for decades with neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

1 reference

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21 January 2018

CSF-biomarkers in Olympic boxing: diagnosis and effects of repetitive head trauma

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21 January 2018

Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.

1 reference

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21 January 2018

Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury.

1 reference

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21 January 2018

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

1 reference

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21 January 2018

Physiological release of endogenous tau is stimulated by neuronal activity.

1 reference

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21 January 2018

Membrane trafficking pathways in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Biochemical markers in persons with preclinical familial Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Alzheimer's disease: a central role for amyloid

1 reference

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21 January 2018

Deciphering Alzheimer disease

1 reference

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21 January 2018

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

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21 January 2018

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

1 reference

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21 January 2018

How can we recognize "disease modification" effects?

1 reference

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21 January 2018

Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Sequence of Abeta-protein deposition in the human medial temporal lobe.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

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21 January 2018

Silver diagnosis in neuropathology: principles, practice and revised interpretation

1 reference

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21 January 2018

Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization.

1 reference

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21 January 2018

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

1 reference

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21 January 2018

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.

1 reference

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21 January 2018

PET amyloid-beta imaging in preclinical Alzheimer's disease

1 reference

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21 January 2018

Tau aggregation is driven by a transition from random coil to beta sheet structure

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival

1 reference

https://api.crossref.org/works/10.1007%2FS00401-013-1139-0

21 January 2018

Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

1 reference

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21 January 2018

Neurochemical aftermath of amateur boxing.

1 reference

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21 January 2018

Low incidence of post-lumbar puncture headache in 1,089 consecutive memory clinic patients

1 reference

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21 January 2018

Perspectives on the amyloid-beta cascade hypothesis

1 reference

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21 January 2018

Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses

1 reference

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21 January 2018

Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt–Jakob disease

1 reference

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21 January 2018

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

1 reference

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21 January 2018

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10.1007/S00401-013-1139-0

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Europe PubMed Central

29 August 2017

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Europe PubMed Central

29 August 2017

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