(Q37978006)

26 August 2017

title

Membrane trafficking pathways in Alzheimer's disease (English)

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26 August 2017

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1

1 reference

26 August 2017

Wim Annaert

2

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26 August 2017

publication date

17 February 2012

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26 August 2017

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26 August 2017

volume

13

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26 August 2017

issue

6

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26 August 2017

page(s)

759-770

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

26 August 2017

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

21 January 2018

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The secretases: enzymes with therapeutic potential in Alzheimer disease

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Potent amyloidogenicity and pathogenicity of Aβ43.

21 January 2018

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

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Trafficking, a key player in regulated intramembrane proteolysis

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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The amyloid precursor protein: beyond amyloid

21 January 2018

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Homo- and heterodimerization of APP family members promotes intercellular adhesion

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

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Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

21 January 2018

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

AICD nuclear signaling and its possible contribution to Alzheimer's disease

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Building gamma-secretase: the bits and pieces

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilin endoproteolysis is an intramolecular cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Glu-333 of nicastrin directly participates in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilins: molecular switches between proteolysis and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Roles of lipid rafts in membrane transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Endocytic trafficking of sphingomyelin depends on its acyl chain length

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Neuronal membrane cholesterol loss enhances amyloid peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilins mediate efficient proteolysis via the autophagosome-lysosome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Prions hijack tunnelling nanotubes for intercellular spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Retromers in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Recent advances in retromer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Model-guided microarray implicates the retromer complex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Retromer disruption promotes amyloidogenic APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Prion protein and Abeta-related synaptic toxicity impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The prion protein as a receptor for amyloid-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Beta-secretase (BACE) as a drug target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Inhibitors and modulators of beta- and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

100 years and counting: prospects for defeating Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2012.01332.X

10.1111/J.1600-0854.2012.01332.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference